Evidence map›Paper›PMID 32179562›Full record

ArticleBMJ open2020

Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial.

Kirstie Louise Lamb, Anthony Lynn, Jean Russell, Margo E Barker

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03621215 (The Effect of Tart Cherry Juice on Risk of Gout Attacks), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03621215 naterminatednot on this map

The Effect of Tart Cherry Juice on Risk of Gout Attacks: a Randomised Controlled Trial

TypeinterventionalSponsorSheffield Hallam UniversityRan2019 to 2021Enrolled38ConditionsGout Flare, Gout AttackArmsTart cherry juice, Fruit-flavoured placebo drink
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kirstie Louise LambFood and Nutrition Group, Sheffield Business School, Sheffield Hallam University, Sheffield, UK kirstie.lamb@student.shu.ac.uk.ORCID 0000-0001-5339-6801
Anthony LynnFood and Nutrition Group, Sheffield Business School, Sheffield Hallam University, Sheffield, UK.
Jean RussellCorporate Information and Computing Services, The University of Sheffield, Sheffield, UK.
Margo E BarkerFood and Nutrition Group, Sheffield Business School, Sheffield Hallam University, Sheffield, UK.
Sheffield Hallam University · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease. Cherries, which are rich in anti-inflammatory and antioxidative bioactive compounds, are proposed to be efficacious in preventing and treating gout, but recommendations to patients are conflicting. Cherry consumption has been demonstrated to lower serum urate levels and inflammation in several small studies. One observational case cross-over study reported that cherry consumption was associated with reduced risk of recurrent gout attacks. This preliminary evidence requires substantiation. The proposed randomised clinical trial aims to test the effect of consumption of tart cherry juice on risk of gout attacks. METHODS AND ANALYSIS: This 12-month, parallel, double-blind, randomised, placebo-controlled trial will recruit 120 individuals (aged 18-80 years) with a clinical diagnosis of gout who have self-reported a gout flare in the previous year. Participants will be randomly assigned to an intervention group, which will receive Montmorency tart cherry juice daily for a 12-month period, or a corresponding placebo group, which will receive a cherry-flavoured placebo drink. The primary study outcome is change in frequency of self-reported gout attacks. Secondary outcome measures include attack intensity, serum urate concentration, fractional excretion of uric acid, biomarkers of inflammation, blood lipids and other markers of cardiovascular risk. Other secondary outcome measures will be changes in physical activity and functional status. Statistical analysis will be conducted on an intention-to-treat basis. ETHICS AND DISSEMINATION: This study has been granted ethical approval by the National Research Ethics Service, Yorkshire and The Humber-Leeds West Research Ethics Committee (ref: 18/SW/0262). Results of the trial will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT03621215.

Indexed as

Fruit and Vegetable JuicesGoutPrunus aviumAdolescentAdultAgedAged, 80 and overBlood PressureHumansMiddle AgedRandomized Controlled Trials as TopicRisk AssessmentUric AcidYoung AdultUric Acidgoutmusculoskeletal disordersnutrition & dieteticsrheumatologytart cherry

Identifiers

PMID32179562
PMCPMC7073821
OpenAlexW3011696470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.