ReviewInternational journal for parasitology. Drugs and drug resistance2020
Drug resistance in liver flukes.
Review in International journal for parasitology. Drugs and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 198 citations in OpenAlex.
- A systematic review of selected food-borne helminthiases in Southeast Asia with emphasis on anthelminthic treatment regimens.Food and waterborne parasitology · 2026Article
- Novel environmental risk index reveals uneven impact of climate change on fascioliasis risk across Africa and Europe.PLoS neglected tropical diseases · 2026Article
- Single-cell transcriptomics identifies a p21-activated kinase important for survival of the zoonotic parasiteiScience · 2026Article
- Lessons on multicellular two- (2D) and three-dimensional (3D) culture in parasitology: Insights, challenges and future directions.International journal for parasitology · 2026Review
- Crafting an innovative one health-aligned machine learning framework for neglected tropical diseases elimination.Journal of advanced research · 2026Article
- A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro.International journal for parasitology. Drugs and drug resistance · 2026Article
- Triclabendazole and Other Fasciolicides: Resistance ofAnimals : an open access journal from MDPI · 2026Review
- Fasciola hepatica in alpine dairy farming: prevalence trends, risk factors and associations with Salmonella Dublin seropositivity.BMC veterinary research · 2026Article
- Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected withVeterinary sciences · 2026Article
- Human infestations with Fasciola hepatica in Austria between 1955 and 2025: data from a low-incidence country.Parasite (Paris, France) · 2026Article
- Assessment of oxidative stress biomarkers in liver flukeVeterinary research forum : an international quarterly journal · 2026Article
- Pharmacokinetic barriers to oxfendazole flukicidal efficacy.PloS one · 2026Article
- "Not a problem because we drench for it": the management of liver fluke on sheep farms.Frontiers in veterinary science · 2026Article
- Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections.Nature communications · 2025Article
- High Efficacy of Triclabendazole/Ivermectin Combination Compared to Triclabendazole Monotherapy for Treating Human Fascioliasis in Upper Egypt: A Prospective Study.Tropical medicine and infectious disease · 2025Article
- Article
- A Modified Variant ofVaccines · 2025Article
- The effects of triclabendazole, combined tetramisole with Oxyclozanide, and albendazole against ovine fasciolosis.Scientific reports · 2025Article
- Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica.Nature communications · 2025Article
- The Clinical Picture Caused byOpen forum infectious diseases · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver flukes include Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Opisthorchis spp., Fascioloides magna, Gigantocotyle explanatum and Dicrocoelium spp. The two main species, F. hepatica and F. gigantica, are major parasites of livestock and infections result in huge economic losses. As with C. sinensis, Opisthorchis spp. and Dicrocoelium spp., they affect millions of people worldwide, causing severe health problems. Collectively, the group is referred to as the Food-Borne Trematodes and their true significance is now being more widely recognised. However, reports of resistance to triclabendazole (TCBZ), the most widely used anti-Fasciola drug, and to other current drugs are increasing. This is a worrying scenario. In this review, progress in understanding the mechanism(s) of resistance to TCBZ is discussed, focusing on tubulin mutations, altered drug uptake and changes in drug metabolism. There is much interest in the development of new drugs and drug combinations, the re-purposing of non-flukicidal drugs, and the development of new drug formulations and delivery systems; all this work will be reviewed. Sound farm management practices also need to be put in place, with effective treatment programmes, so that drugs can be used wisely and their efficacy conserved as much as is possible. This depends on reliable advice being given by veterinarians and other advisors. Accurate diagnosis and identification of drug-resistant fluke populations is central to effective control: to determine the actual extent of the problem and to determine how well or otherwise a treatment has worked; for research on establishing the mechanism of resistance (and identifying molecular markers of resistance); for informing treatment options; and for testing the efficacy of new drug candidates. Several diagnostic methods are available, but there are no recommended guidelines or standardised protocols in place and this is an issue that needs to be addressed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.