Evidence map›Paper›PMID 32179470›Full record

ArticleiScience2020

TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma.

Nabanita Roy Chattopadhyay, Koustav Chatterjee, Nikhil Tiwari, Sudipta Chakrabarti, Sushil Kumar Sahu, Sankar Deb Roy, Arijit Ghosh, R Rajendra Reddy, Piyanki Das, Sudipa Mal and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 2 countries.

Nabanita Roy ChattopadhyayDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
Koustav ChatterjeeDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
Nikhil TiwariSchool of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India.
Sudipta ChakrabartiMidnapore City College, Kuturia, Bhadutala, PaschimMedinipur 721129, India.
Sushil Kumar SahuDepatrment of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sankar Deb RoyDepartment of Radiation Oncology, Eden Medical Center, Dimapur, Nagaland 797112, India.
Arijit GhoshSchool of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India.
R Rajendra ReddyClinical Proteomics, Institute of Life Sciences, 751023 Bhubaneswar, India.
Piyanki DasDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
Sudipa MalDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
Basab Bijay KarnarDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India.
Ashok Kumar DasDr B. Borooah Cancer Institute, ENT Department, Guwahati, Assam 781016, India.
Sam TseringTertiary Cancer Center, TomoRiba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh 791110, India.
Komri RibaTertiary Cancer Center, TomoRiba Institute of Health and Medical Sciences, Naharlagun, Arunachal Pradesh 791110, India.
Zoreng PuiiState Referral Hospital, Falkawn, Mizoram 796005, India.
Eric ZomawiaState Referral Hospital, Falkawn, Mizoram 796005, India.
Y Indibar SinghDepartment of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur 795004, India.
Amol Ratnakar SuryawanshiClinical Proteomics, Institute of Life Sciences, 751023 Bhubaneswar, India.
Abhishek KumarInstitute of Bioinformatics, International Technology Park, 560100 Bangalore, India; Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.
Dipyaman GangulyDendritic Cell Laboratory, Cancer Biology and Inflammatory Disorder, Indian Institute of Chemical Biology, 700032 Kolkata, India.
Chandan GoswamiSchool of Biological Science, National Institute of Science Education and Research, Padnpur, Odisha 752050, India.
Tathagata ChoudhuriDepartment of Biotechnology, Visva Bharati, Santiniketan, Bolpur 731235, India. Electronic address: tathagata.choudhuri@visva-bharati.ac.in.
Visva-Bharati University · INNational Institute of Science Education and Research · INInstitute of Life Sciences · INBhubaneswar Borooah Cancer Institute · INIndian Institute of Chemical Biology · INInstitute of Bioinformatics · INJohns Hopkins University · USMidnapore Medical College and Hospital · INRegional Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of <0.0001 at a significance level of 0.05. These might play an important role for the lack of function of TLR9 and thus for the higher occurrence of EBV-mediated NPC in such ethnic groups.

Indexed as

Biological SciencesCancerHuman Genetics

Identifiers

PMID32179470
PMCPMC7068130
OpenAlexW3007136505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.