Evidence map›Paper›PMID 32179424›Full record

ArticleEuropean journal of radiology2020

Magnetic resonance elastography vs. point shear wave ultrasound elastography for the assessment of renal allograft dysfunction.

Paul Kennedy, Octavia Bane, Stefanie J Hectors, Sonja Gordic, Mark Berger, Veronica Delaney, Fadi Salem, Sara Lewis, Madhav Menon, Bachir Taouli

Open access · greenAbstract readComparative Study
In one paragraph

Article in European journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Doppler ultrasound for the evaluation of chronic renal allograft dysfunction.Quantitative imaging in medicine and surgery · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Paul KennedyBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States.
Octavia BaneBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States.
Stefanie J HectorsBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States; Department of Radiology, Weill Cornell Medicine, United States.
Sonja GordicBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
Mark BergerDepartment of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, United States.
Veronica DelaneyDivision of Renal Medicine, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, United States.
Fadi SalemDepartment of Pathology, Icahn School of Medicine at Mount Sinai, United States.
Sara LewisBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, United States.
Madhav MenonDivision of Renal Medicine, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, United States.
Bachir TaouliBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, United States; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, United States. Electronic address: bachir.taouli@mountsinai.org.
Icahn School of Medicine at Mount Sinai · US

Funding

Dichotomous roles of Shroom3 in Tubular cells and Podocytes in native and allograft kidneysR01DK122164 · NIDDK · YALE UNIVERSITY · PI Madhav C Menon · 2019 to 2026
$2.7M
Prediction of portal pressure with liver and spleen MR Elastography and 4D flow phase-contrast MRIR01DK113272 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TAOULI, BACHIR · 2018 to 2021
$2.0M
Quantification of Renal Perfusion, Diffusion and Hypoxia Using Advanced MRI Methods for Assessment of Renal Transplant DysfunctionF32DK109591 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BANE, OCTAVIA · 2016 to 2018
$126k
NIDDK NIH HHS F32 DK109591NIDDK NIH HHS R01 DK113272NIDDK NIH HHS R01 DK122164
6 · The paper itself

Abstract

purposeTo investigate the utility of magnetic resonance elastography (MRE) vs. ultrasound (US) point shear wave elastography (pSWE) for the assessment of chronic renal allograft dysfunction, prediction of outcome and determine the correlation with Banff pathology scores.

methodsIn this IRB approved prospective study, 27 enrolled patients with functional (n = 15) and chronic dysfunctional (n = 12) renal allografts underwent same day 2D MRE and pSWE. Histogram parameters [including mean, median, standard deviation, kurtosis and skewness] of the magnitude of the complex shear modulus (MRE) and median Young's modulus (pSWE) were measured in the cortex (MRE and pSWE) and combined corticomedullary regions (MRE). Histopathology was available for 16 patients (4 functional, 12 dysfunctional).

resultsMRE and pSWE stiffness were not significantly different between functional and dysfunctional groups (p range 0.139-0.347). The skewness of MRE corticomedullary stiffness was significantly lower (p = 0.04) in patients with chronic dysfunction and correlated significantly with Banff histopathologic scores (range r=-0.518-0.567, p = 0.035-0.040). MRE cortical and corticomedullary mean stiffness showed strong performance in predicting graft loss/relist (AUC 0.958, p = 0.011 for both). Reliable pSWE measurements were obtained in 13 patients (48 %). pSWE stiffness did not correlate with Banff scores and did not predict outcome.

conclusionsThe skewness of MRE corticomedullary stiffness is sensitive to changes in chronic allograft dysfunction, while mean/median MRE renal stiffness and median US stiffness did not differentiate patients with stable function vs those with chronic renal allograft dysfunction. MRE corticomedullary mean stiffness appears to be a predictor of graft loss/relist. pSWE was not found to be a useful method for assessing renal allografts.

Indexed as

Kidney TransplantationAdultAgedAllograftsElasticity Imaging TechniquesElastic ModulusFemaleHumansKidneyMagnetic Resonance ImagingMaleMiddle AgedPostoperative ComplicationsProspective StudiesReproducibility of ResultsTransplantation, HomologousAllograftDysfunctionElasticity imaging techniquesFibrosis

Identifiers

PMID32179424
PMCPMC7210723
OpenAlexW3010797546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.