Evidence map›Paper›PMID 32179280›Full record

ArticleBioorganic chemistry2020

Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae).

Isaac T Henneh, Boshi Huang, Faik N Musayev, Rana Al Hashimi, Martin K Safo, Francis A Armah, Elvis O Ameyaw, Christian K Adokoh, Martins Ekor, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Endophytic fungi from Cissus quadrangularis plant a promising source of bioactive compounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  3. AnHeliyon · 2024
    Article
  4. Review
  5. Article
  6. Toxicology reports · 2022
    Article
  7. Histochemical and Phytochemical Analysis ofMolecules (Basel, Switzerland) · 2021
    Article
  8. Analgesic Effect ofFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isaac T HennehDepartment of Pharmacology, School of Medical Sciences, University of Cape Coast, P.M.B. University Post Office, Cape Coast, Ghana.
Boshi HuangDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States.
Faik N MusayevDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States; The Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Rana Al HashimiDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States; The Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Martin K SafoDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States; The Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Francis A ArmahDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, P.M.B. University Post Office, Cape Coast, Ghana.
Elvis O AmeyawDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, P.M.B. University Post Office, Cape Coast, Ghana.
Christian K AdokohDepartment of Forensic Sciences, School of Biological Sciences, University of Cape Coast, P.M.B. University Post Office, Cape Coast, Ghana.
Martins EkorDepartment of Pharmacology, School of Medical Sciences, University of Cape Coast, P.M.B. University Post Office, Cape Coast, Ghana. Electronic address: m.ekor@uccsms.edu.gh.
Yan ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States. Electronic address: yzhang2@vcu.edu.

Funding

Non-peptide Mu Opioid Receptor Selective AntagonistsR01DA024022 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZHANG, YAN · 2009 to 2019
$3.5M
Hemoglobin Modifiers for Sickle Cell Disease TherapyR01MD009124 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2014 to 2018
$2.1M
X-ray Crystallographic Data Collection SystemS10OD021756 · OD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2017 to 2017
$600k
NIDA NIH HHS R01 DA024022NIH HHS S10 OD021756NIMHD NIH HHS R01 MD009124
6 · The paper itself

Abstract

Two natural products, compounds 1 and 2 were isolated from the root bark of Ziziphus abyssinica for the first time and were structurally elucidated as β-amyrin and polpunonic acid, respectively. Both compounds were further subjected to an in vivo study in rats to evaluate their anti-arthritic potency. Compared to the arthritic control group, rats treated with different doses of 1 or 2 (3, 10, and 30 mg/kg) exhibited significantly higher total change in body weight as well as lower arthritic scores and total change in paw edema and erythema. Histopathological examinations of the hind paws of the rats further demonstrated the beneficial effects of both compounds as they significantly reversed cartilage erosion, subchondral cyst, and Weichselbaum's lacunae formation. Evidence of bone remodeling was also observed in all groups of rats treated with 1 or 2. Hematological and serum biochemical parameters were not significantly affected by treatment of 1 or 2. Taken together, the results from the present study suggest potential therapeutic benefit of β-amyrin and polpunonic acid in rheumatoid arthritis and related inflammatory disorders.

Indexed as

AnalgesicsAnimalsAnti-Inflammatory AgentsArthritis, ExperimentalDose-Response Relationship, DrugEdemaFemaleFreund's AdjuvantMaleMolecular StructureOleanolic AcidPlant BarkPlant RootsRatsRats, Sprague-DawleyRhamnaceaeAnalgesicsAnti-Inflammatory Agentsbeta-amyrinFreund's Adjuvantmaytenonic acidOleanolic AcidTriterpenesAnti-arthritic activityPolpunonic acidStructural elucidationZiziphus abyssinicaβ-Amyrin

Identifiers

PMID32179280
PMCPMC11294980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.