ArticleAmerican heart journal2020
Risk of major cardiovascular and neurologic events with obstructive sleep apnea among patients with atrial fibrillation.
Article in American heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Sleep Disorder Phenotypes and the Risk of Incident Heart Failure:Saudi medical journal · 2026Pooled it
- [A long-term ischemic stroke risk score model in patients aged 60 years and older with obstructive sleep apnea: a multicenter prospective cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Trial
- Article
- [Effect of simultaneous multi-plane surgery on cardiopulmonary function in patients with obstructive sleep apnea-hypopnea syndrome and its curative effect].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Prevalence and Diagnosis of Obstructive Sleep Apnea in Atrial Fibrillation Patients: A Systematic Review.Journal of clinical medicine · 2025Review
- Clinical and economic outcomes with rivaroxaban versus warfarin in patients with nonvalvular atrial fibrillation and obstructive sleep apnea: retrospective analysis of US healthcare claims.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Coexistence: From Pathophysiology to Clinical Complications.International journal of chronic obstructive pulmonary disease · 2025Review
- Role of sleep disorders in patients with cardiovascular disease: A systematic review.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Association Between Sleep Apnea Treatment and Health Care Resource Use in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2024Article
- Review
- Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study.Journal of personalized medicine · 2023Article
- LncRNA XR_595552 inhibition alleviates intermittent hypoxia-induced cardiomyocyte damage via activating the PI3K/AKT pathway.Sleep & breathing = Schlaf & Atmung · 2023Article
- Clinical characteristics and thrombotic risk of atrial fibrillation with obstructive sleep apnea: results from a multi-center atrial fibrillation registry study.BMC cardiovascular disorders · 2022Article
- Protocol for detecting unrecognized sleep apnea in patients with atrial fibrillation by a home-monitoring device: the DAN-APNO study.BMC cardiovascular disorders · 2022Article
- Effect of Simultaneous Multiplane Surgery on Cardiopulmonary Function in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome and Its Curative Effect.BioMed research international · 2022Article
- The effect of obesity, hypertension, diabetes mellitus, alcohol, and sleep apnea on the risk of atrial fibrillation.Physiological research · 2021Review
- Should we incorporate obstructive sleep apnea in CHA2DS2-VASc score?Sleep & breathing = Schlaf & Atmung · 2021Article
- Optimizing indices of atrial fibrillation susceptibility and burden to evaluate atrial fibrillation severity, risk and outcomes.Cardiovascular research · 2021Review
- Predicting Incident Atrial Fibrillation Using Single Channel Nocturnal Oximetry: Can Necessity Become the Mother of Intervention?Annals of the American Thoracic Society · 2021Article
- Sleep Disorders in Stroke: An Update on Management.Aging and disease · 2021Review
Corrections and comments
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Authors and funding
17 authors at 14 institutions in 2 countries.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF). However, it remains unclear whether OSA is independently associated with worse cardiovascular and neurological outcomes in patients with AF.
methodsWe used the ORBIT-AF I and ORBIT-AF II to conduct a retrospective cohort study of 22,760 patients with AF with and without OSA. Adjusted multivariable Cox proportional hazards models was used to determine whether OSA was associated with increased risk for major adverse cardiac and neurologic events (MACNEs) (cardiovascular death, myocardial infarction, stroke/transient ischemic attack/non-central nervous system embolism (stroke/SE), and new-onset heart failure], combined and individually.
resultsA total of 4,045 (17.8%) patients had OSA at baseline. Median follow-up time was 1.5 (interquartile range: 1-2.2) years, and 1,895 patients experienced a MACNE. OSA patients were younger (median [interquartile range] 68 [61-75] years vs 74 [66-81] years), were more likely male (70.7% vs 55.3%), and had increased body mass index (median 34.6 kg/m
conclusionsAmong patients with AF, OSA is an independent risk factor for MACNE and, more specifically, stroke/SE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.