SynthesisTravel medicine and infectious disease
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis.
Synthesis in Travel medicine and infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 10 registered trials, which are not on this map. Cited by 1,170 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Point Of Care UltraSonography to Perform Risk-stratification of Patients With Suspected or Confirmed COVID-19 - POCUSCO Study
Efficacy and Safety of Treatment With Convalescent Plasma for Adults With COVID-19 Pneumonia. A Double-blinded, Randomized, Multicenter Placebo-controlled Trial
Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19: A Descriptive, Longitudinal, Pragmatic Cohort Study
Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection
Prophylaxis With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19)
Amantadine for COVID-19: A Randomized, Placebo Controlled, Double-blinded, Clinical Trial
Evaluation of The Efficacy of Nigella Sativa Versus VitaminD3 as Supplement Therapy in Management of Coronavirus Disease 2019 (COVID-19)
Effects of Aerobic Exercise in People With Post-COVID-19: a Randomized Controlled Trial
Retrospective Study of COVID-19 on Reproductive Function and Assisted Reproductive Technology Pregnancy Outcome in China
The Effects and Underlying Mechanisms of Novel Coronavirus Infection on Reproductive Function and Assisted Pregnancy Outcome
Who cites it
1,170 citing papers in PubMed, 11 syntheses or guidelines pooled it, 2,488 citations in OpenAlex.
- Neurocognitive Impairment in Long COVID: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Pooled it
- The effect of pulmonary rehabilitation for post-acute sequelae of SARS-CoV-2 infection in patients: a systematic review and meta-analysis.Frontiers in rehabilitation sciences · 2025Pooled it
- Pooled it
- Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection.Biochemical genetics · 2024Pooled it
- Cerebrospinal fluid cytokines in COVID-19: a review and meta-analysis.Journal of neurology · 2023Pooled it
- Diagnostic accuracy of clinical signs and symptoms of COVID-19: A systematic review and meta-analysis to investigate the different estimates in a different stage of the pandemic outbreak.Journal of global health · 2023Pooled it
- Attention and memory after COVID-19 as measured by neuropsychological tests: Systematic review and meta-analysis.Acta psychologica · 2023Pooled it
- Auxiliary screening COVID-19 by computed tomography.Frontiers in public health · 2023Pooled it
- A systematic review of whether COVID-19 randomized controlled trials reported on demographic and clinical characteristics.Pharmacoepidemiology and drug safety · 2022Pooled it
- High prevalence of SARS-CoV-2 detection and prolonged viral shedding in stools: A systematic review and cohort study.Gastroenterologia y hepatologia · 2022Pooled it
- Lymphocyte count is a universal predictor of health outcomes in COVID-19 patients before mass vaccination: A meta-analytical study.Journal of global health · 2022Pooled it
- Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial.International journal of clinical practice · 2023Trial
- Intranasal Corticosteroid Treatment on Recovery of Long-Term Olfactory Dysfunction Due to COVID-19.The Laryngoscope · 2022Trial
- Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial.The European respiratory journal · 2022Trial
- Comparison of prevalence and outcomes of SARS-CoV-2 infection between preterm and full-term children after lifting the prevention and control measures in China: a nationwide cross-sectional survey.BMC infectious diseases · 2026Article
- Osegnet-F-Unext: O-Segnet-Fusion-Unext for pulmonary lobe segmentation of Covid-19 using Computed Tomography image.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Physical function of patients with severe COVID-19 pneumonia requiring invasive mechanical ventilation: an observational study.Singapore medical journal · 2026Article
- A Human β-Defensin-Based Recombinant Protein DFCells · 2026Article
- Proposed intensive care unit triage models lack predictive validity for hospital mortality to deal with catastrophes: insights from a cohort study.Critical care science · 2026Article
- Opportunities and Challenges in Gas Sensor Technologies for Accurate Detection of COVID-19.Biosensors · 2025Review
1,110 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 15 institutions in 14 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAn epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date.
methodsWe performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI).
results660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 95%CI 40.8-74.4%) and dyspnea (45.6%, 95%CI 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).
conclusionCOVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.