ReviewPharmacology, biochemistry, and behavior2020
Effect of alcohol use on the adolescent brain and behavior.
Review in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
214 citing papers in PubMed, 6 syntheses or guidelines pooled it, 388 citations in OpenAlex.
- Parallel addictions: understanding the psychological and neurobehavioral damage of gaming and alcohol use in adolescents and young adults.Frontiers in psychology · 2026Pooled it
- Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth.Current neuropharmacology · 2025Pooled it
- Does geographic availability of alcohol influence drinking in adolescents? A systematic review of literature associations.Health & place · 2024Pooled it
- Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Prevalence of parental supply of alcohol to minors: a systematic review.Health promotion international · 2023Pooled it
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- A randomized controlled trial testing the efficacy of the eCHECKUP TO GO on drinking games participation and behavior among high school seniors.Addictive behaviors · 2025Trial
- Whole-brain mechanism of neurofeedback therapy: predictive modeling of neurofeedback outcomes on repetitive negative thinking in depression.Translational psychiatry · 2024Trial
- N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice.Hippocampus · 2026Article
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Blaming the Patient: The Ethical Failures of Responsibility-Based Liver Transplant Policy in Alcohol Use Disorder.Bioethics · 2026Article
- Developmental Timing of Alcohol Initiation as a Marker of Adult Clinical Complexity in Alcohol Use Disorder: A Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Review of the Characteristics of School-Based Integrated Mental Health and Substance Use Prevention Programs for Adolescents Evaluated Through Clinical Trials Between 2016 and 2026.Children (Basel, Switzerland) · 2026Review
- Structural and Intermediate Social Determinants of Health Linked to Adolescent Pregnancy in the Peruvian Rural Context.International journal of environmental research and public health · 2026Article
- An Interactive Narrative Intervention to Increase Adolescents' Knowledge and Self-Efficacy to Reduce Alcohol Use: Pre-Post Study.JMIR formative research · 2026Article
- Alcohol and Energy Drink Use Among Adolescents and Young Adults: Insights from the ALIMA Study.Nutrients · 2026Article
- Effects of a Mobile Application "Teenagers Don't Drink" on Preventing Alcohol Consumption among Thai Adolescents: A Quasi-experimental Study.International journal of community based nursing and midwifery · 2026Article
- Loneliness and nervousness mediate the association between alcohol use and cyberbullying victimization among school-aged adolescents: a two-year longitudinal study.BMC psychology · 2026Article
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Adolescence is a particularly vulnerable neurodevelopmental period marked by high rates of engagement with risky alcohol use. This review summarizes the cognitive and neural consequences following alcohol use during adolescence from longitudinal design studies in humans and animals. Findings from human adolescent studies suggest that binge drinking and heavy alcohol use is associated with poorer cognitive functioning on a broad range of neuropsychological assessments, including learning, memory, visuospatial functioning, psychomotor speed, attention, executive functioning, and impulsivity. Alcohol use during adolescence is associated with accelerated decreases in gray matter and attenuated increases in white matter volume, and aberrant neural activity during executive functioning, attentional control, and reward sensitivity tasks, when compared to non-drinking adolescents. Animal studies in rodents and non-human primates have replicated human findings, and suggest cognitive and neural consequences of adolescent alcohol use may persist into adulthood. Novel rodent studies demonstrate that adolescent alcohol use may increase reward responsiveness of the dopamine system to alcohol later in life, as well as disrupt adolescent neurogenesis, potentially through neuroinflammation, with long-lasting neural and behavioral effects into adulthood. Larger longitudinal human cognitive and neuroimaging studies with more diverse samples are currently underway which will improve understanding of the impact of polysubstance use, as well as the interactive effects of substance use, physical and mental health, and demographic factors on cognition and neurodevelopment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.