Evidence map›Paper›PMID 32179027›Full record

ArticlePharmacology, biochemistry, and behavior2020

Environmental enrichment and a selective metabotropic glutamate receptor

Erik J Garcia, Mary E Cain

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Erik J GarciaDepartment of Psychological Sciences, Kansas State University, United States of America.
Mary E CainDepartment of Psychological Sciences, Kansas State University, United States of America. Electronic address: mecain@ksu.edu.
Kansas State University · US

Funding

The Effects of Differential Rearing on Glutamate Homeostasis and AddictionR15DA035435 · NIDA · KANSAS STATE UNIVERSITY · PI CAIN, MARY EILEEN · 2013 to 2018
$945k
NIDA NIH HHS R15 DA035435
6 · The paper itself

Abstract

A challenge for developing effective treatments for substance use disorders (SUDs) is understanding how environmental variables alter the efficacy of therapeutics. Environmental enrichment (EC) enhances brain development and protects against behaviors associated with drug abuse vulnerability when compared to rats reared in isolation (IC) or standard conditions (SC). EC rearing enhances the expression and function of metabotropic glutamate receptor

Indexed as

EnvironmentAmino AcidsAmphetamineAnimalsBehavior, AnimalBridged Bicyclo Compounds, HeterocyclicCentral Nervous System StimulantsDose-Response Relationship, DrugMaleMotivationRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateReinforcement ScheduleSelf AdministrationSocial IsolationAmino AcidsAmphetamineBridged Bicyclo Compounds, HeterocyclicCentral Nervous System StimulantsLY 379268metabotropic glutamate receptor 2metabotropic glutamate receptor 3Receptors, Metabotropic GlutamateAmphetamine self-administration (AMP SA)Environmental enrichment and differential rearingMetabotropic glutamate receptors (mGluR)Progressive ratio schedule of reinforcementStatistical inference

Identifiers

PMID32179027
PMCPMC7192569
OpenAlexW3011574034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.