Observational studyJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020
Early Cognitive Impairment after Minor Stroke: Associated Factors and Functional Outcome.
Observational study in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT05565976. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dapagliflozin Effect in Cognitive Impairment in Stroke Trial
Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- A qEEG-based prognostic model for cognitive impairment after ischemic stroke: Development and internal validation.IBRO neuroscience reports · 2026Article
- APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.BMC neurology · 2025Article
- Characteristics of subacute stroke patients who achieve earlier independence in real-life walking performance during hospitalization.Journal of rehabilitation medicine · 2025Article
- Risk Factors and Clinical Significance of Ultra-Long-Term Microischemia After Intracranial Aneurysm Embolization.Neurology and therapy · 2024Article
- Evaluation of the functional outcome and mobility of patients after stroke depending on their cognitive state.Scientific reports · 2024Article
- Elevated serum uric acid is associated with cognitive impairment in acute minor ischemic stroke patients.Heliyon · 2023Article
- Association of Temporalis Muscle Mass with Early Cognitive Impairment in Older Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2023Article
- Outcomes in Patients with Minor Stroke: Diagnosis and Management in the Post-thrombectomy Era.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Leukoaraiosis as a Predictor of Depression and Cognitive Impairment among Stroke Survivors: A Systematic Review.Neurology international · 2023Review
- Correlation BetweenClinical interventions in aging · 2023Article
- Persisting cognitive impairment predicts functional dependence at 1 year after stroke and transient ischemic attack: a longitudinal, cohort study.BMC geriatrics · 2022Article
- Disparities in Stroke: Associating Socioeconomic Status With Long-Term Functional Outcome After Mechanical Thrombectomy.Stroke (Hoboken, N.J.) · 2022Article
- The montreal cognitive assessment and mini-mental state examination visuoexecutive subtests in acute ischemic stroke patients and their correlations with demographic and clinical factors.Acta neurologica Belgica · 2021Article
- Methylation of theNeuropsychiatric disease and treatment · 2021Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEvaluation of cognitive status is not performed routinely in the acute stroke setting. This study aimed to evaluate the frequency of early cognitive impairment in patients with minor ischemic stroke, analyze the factors associated with early cognitive impairment, and assess functional outcomes.
methodsIn this prospective study, 112 consecutive patients with acute minor ischemic stroke were enrolled. Neuroimages were assessed for semiquantitative evaluation of brain atrophy and small vessel disease (SVD) markers. Cognitive performance was measured within 5 days of onset using Montreal Cognitive Assessment (MoCA) scores. Functional outcome analyses were adjusted for demographic variables, premorbid cognitive status, education level, vascular risk factors, neuroimaging characteristics, stroke severity, and MoCA scores.
resultsThe median MoCA score was 22, and 63% of patients had cognitive impairment. Factors independently associated with cognitive impairment were education (odds ratios [OR], .79; confidence intervals [CI], .63-.99), smoking (OR, .26; 95%CI, .073-.89), and temporal horn atrophy (OR, 4.73; 95% CI, 1.66-13.49). Factors independently associated with poor functional outcome were total MoCA score (OR, .78; 95%CI, .62-.95) and the sum of 4 MoCA subscores (visuospatial/executive, attention, language, and orientation; OR, .72; 95%CI, .53-.92). The cutoff value of the sum of 4 MoCA subscores for predicting poor outcome was 13 points with 76.5% sensitivity and 81.1% specificity.
conclusionsEarly cognitive impairment was common after minor ischemic stroke and was associated with preexisting temporal horn atrophy but not SVD markers. The sum of 4 MoCA subscores was useful in predicting the functional outcome.
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