Evidence map›Paper›PMID 32178769›Full record

ReviewLancet (London, England)2020

COVID-19 and Italy: what next?

Andrea Remuzzi, Giuseppe Remuzzi

12 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Lancet (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 12 registered trials, which are not on this map. Cited by 1,406 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,406citing papers in PubMed, 5 pooled it
264.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04340349 early_phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals (ELEVATE Trial)

TypeinterventionalSponsorInstituto Nacional de RehabilitacionRan2021 to 2021Enrolled214ConditionsHydroxychloroquine, Antimalarials, Enzyme Inhibitors, Antirheumatic AgentsArmsHydroxychloroquine Sulfate, Bromhexine 8 MG
NCT04342637 completednot on this map

Gastrointestinal Endoscopy in the Era of COVID-19: a Multinational Survey

TypeobservationalSponsorAl-Azhar UniversityRan2020 to 2020Enrolled163ConditionsCOVID-19ArmsPractice details
NCT04365517 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients

TypeinterventionalSponsorUniversity of MilanRan2021 to 2022Enrolled170ConditionsCovid19, Diabetes Mellitus, Type 2, CKDArmsSitagliptin
NCT04379544 completednot on this map

Prognostic Value of Point of Care Cardiac and Lung Ultrasound in COVID-19

Typeobservational_patient_registrySponsorUniversity of PennsylvaniaRan2020 to 2021Enrolled125ConditionsCoronavirus, Respiratory FailureArmsObservation only
NCT04382794 completednot on this map

Sitagliptin Treatment in Diabetic COVID-19 Positive Patients: Retrospective Study

TypeobservationalSponsorUniversity of MilanRan2020 to 2020Enrolled338ConditionsCovid19ArmsRetrospective case-control analysis
NCT04387890 unknown statusnot on this map

Serologic Surveillance for SARS-CoV-2 (COVID-19) in a Prospective Cohort of Health Care

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2020 to 2020Enrolled50ConditionsCOVID-19, SARS-CoV 2, Health PersonnelArmsSerologic SARS-CoV-2 screening
NCT04395482 completednot on this map

Lung CT Scan Analysis of SARS-CoV2 Induced Lung Injury by Machine Learning: a Multicenter Retrospective Cohort Study.

TypeobservationalSponsorUniversity of Milano BicoccaRan2020 to 2022Enrolled44Conditionscovid19ArmsLung CT scan analysis in COVID-19 patients
NCT04420260 nacompletednot on this mapstarted 2021, after this paper: background citation

Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia

TypeinterventionalSponsorUnidad de Investigación Genética MolecularRan2021 to 2021Enrolled152ConditionsCOVIDArmsGroup A: oropharygeal spray and immunostimulant emulsion, Group D:Placebo oropharyngeal spray + Placebo taken PO
NCT04531774 naunknown statusnot on this map

RECHARGE: A Brief Psychological Intervention to Build Resilience in Healthcare Workers During COVID-19

TypeinterventionalSponsorNaser MorinaRan2020 to 2021Enrolled160ConditionsStress, Burnout, Anxiety, DepressionArmsRECHARGE, Self Study
NCT04609774 completednot on this map

Aerosol Transmission of Severe Acute Respiratory Syndrome Coronavirus: a Dilemma

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2020 to 2020Enrolled8ConditionsCoronavirus Disease (COVID-19)ArmsSevere Acute Respiratory Syndrome CoronaVirus 2 detection
NCT04617119 naunknown statusnot on this map

The Effects of Multi-modality Physiotherapy in Delaying or Preventing COVID-19 Patient From Admitting to ICU: A Pilot Study

TypeinterventionalSponsorDR. JASSIM ALGHAITHRan2020 to 2021Enrolled38ConditionsCovid19, Severe Systemic Illness Respiratory Muscle FatigueArmsThreshold IMT device, Conventional physical therapy
NCT05036824 unknown statusnot on this mapstarted 2021, after this paper: background citation

Intensive Dose Tinzaparin in Hospitalized COVID19 Patients

TypeobservationalSponsorUniversity Hospital of PatrasRan2021 to 2022Enrolled300ConditionsCovid19, HospitalizationArmstinzaparin
3 · Its place in the literature

Who cites it

1,406 citing papers in PubMed, 5 syntheses or guidelines pooled it, 3,347 citations in OpenAlex.

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  4. What Makes Urban Communities More Resilient to COVID-19? A Systematic Review of Current Evidence.International journal of environmental research and public health · 2022
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  7. Minimizing Societal Cost of Epidemics: Optimal Catastrophe Insurance Compensation Allocation.Risk analysis : an official publication of the Society for Risk Analysis · 2026
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1,346 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrea RemuzziDepartment of Management Information and Production Engineering, University of Bergamo, Dalmine, Italy. Electronic address: andrea.remuzzi@unibg.it.
Giuseppe RemuzziIstituto di Ricerche Farmacologiche Mario Negri IRCCS.
Istituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Bergamo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already taken on pandemic proportions, affecting over 100 countries in a matter of weeks. A global response to prepare health systems worldwide is imperative. Although containment measures in China have reduced new cases by more than 90%, this reduction is not the case elsewhere, and Italy has been particularly affected. There is now grave concern regarding the Italian national health system's capacity to effectively respond to the needs of patients who are infected and require intensive care for SARS-CoV-2 pneumonia. The percentage of patients in intensive care reported daily in Italy between March 1 and March 11, 2020, has consistently been between 9% and 11% of patients who are actively infected. The number of patients infected since Feb 21 in Italy closely follows an exponential trend. If this trend continues for 1 more week, there will be 30 000 infected patients. Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. Our analysis might help political leaders and health authorities to allocate enough resources, including personnel, beds, and intensive care facilities, to manage the situation in the next few days and weeks. If the Italian outbreak follows a similar trend as in Hubei province, China, the number of newly infected patients could start to decrease within 3-4 days, departing from the exponential trend. However, this cannot currently be predicted because of differences between social distancing measures and the capacity to quickly build dedicated facilities in China.

Indexed as

BetacoronavirusAdultAgedAged, 80 and overCoronavirus InfectionsCOVID-19FemaleGlobal HealthHealth PolicyHospital Bed CapacityHumansIntensive Care UnitsItalyMaleMiddle AgedModels, Biological

Identifiers

PMID32178769
PMCPMC7102589
OpenAlexW3011242477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 6 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.