ArticleMolecular brain2020
Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice.
Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dynamic representations of valence in anterior cingulate cortex in mice.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Dmrt2 regulates sex-biased neuronal development in the cingulate cortex.Cellular and molecular life sciences : CMLS · 2025Article
- Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Review
- Sex differences in glutamate transmission and plasticity in reward related regions.Frontiers in behavioral neuroscience · 2024Review
- Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine.iScience · 2023Article
- Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice.Molecular brain · 2023Article
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex.Biomedicines · 2022Review
- Different Synaptic Plasticity After Physiological and Psychological Stress in the Anterior Insular Cortex in an Observational Fear Mouse Model.Frontiers in synaptic neuroscience · 2022Article
- Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity.Neuropsychiatric disease and treatment · 2021Review
- Article
- NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice.Molecular painArticle
- Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice.Molecular painArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term depression (LTD). However, it is unclear whether there is a sex difference at synaptic level. Recent studies indicate that excitatory transmission and plasticity in the anterior cingulate cortex (ACC) are critical in chronic pain and pain related emotional responses. In the present study, we used 64-channel multielectrode (MED64) system to record synaptic plasticity in the ACC of male and female adult mice. We found that there was no significant difference in theta-burst stimulation (TBS)-induced LTP between female and male mice. Furthermore, the recruitment of inactive channels was also not different. For LTD, we found that LTD was greater in slices of ACC in male mice than female mice. Our results demonstrate that LTP in the ACC does not show any sex-related difference.
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