ArticleEnvironmental health : a global access science source2020
Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study.
Article in Environmental health : a global access science source, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Cockroach gut microbiota is a significant source of endotoxin, a risk factor for asthma in cockroach-infested homes.Journal of medical entomology · 2026Article
- Indoor allergens and endotoxins in relation to cockroach infestations in low-income urban homes.The journal of allergy and clinical immunology. Global · 2026Article
- Epigenetic age acceleration and mortality risk prediction in US adults.GeroScience · 2025Article
- Overlap prevalence and interaction effect of cardiometabolic risk factors for metabolic dysfunction-associated steatotic liver disease.Nutrition & metabolism · 2025Article
- Prenatal and postnatal exposure to organophosphate esters and replacement flame retardant mixtures and childhood respiratory outcomes.Environmental research · 2025Article
- Joint association of indoor allergens, endotoxins, heavy metals, and parabens with allergy-related outcomes in U. S. adults.Frontiers in public health · 2025Article
- Baseline Estimates for Companion Animals Living in Households in Hawai'i: Associated Socio-Demographic, and Select Health Variables, as Measured by a Household Survey.Hawai'i journal of health & social welfare · 2025Article
- Prevalence of indoor air pollutants from First Nation homes in North Central British Columbia, Canada.International journal of circumpolar health · 2024Article
- Epigenetic age acceleration and mortality risk prediction in U.S. adults.medRxiv : the preprint server for health sciences · 2024Article
- Article
- A nationwide cross-sectional survey of episiotomy practice in China.The Lancet regional health. Western Pacific · 2022Article
- Multi-Level Socioenvironmental Contributors to Childhood Asthma in New York City: a Cluster Analysis.Journal of urban health : bulletin of the New York Academy of Medicine · 2021Article
- Effects of early-life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study.Clinical and translational allergy · 2021Article
- Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America.International journal of environmental research and public health · 2021Article
- Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction.Journal of asthma and allergy · 2021Review
- Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Article
- [Association of theZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEndotoxin is ubiquitous in the environment, but its clustering with indoor allergens is not well characterized. This study examined the clustering patterns of endotoxin with allergens in house dust and their association with asthma outcomes.
methodsWe analyzed data from 6963 participants of the 2005-2006 National Health and Nutrition Examination Survey. House dust sampled from bedroom floor and bedding was evaluated for endotoxin and allergens from fungi, cockroach, dog, cat, mites, and rodents. Two-step cluster analysis and logistic regressions were performed to identify the clustering patterns and their associations with current asthma and wheeze in the past 12 months, adjusting for covariates.
resultsOf the homes, 17.8% had low endotoxin and allergen levels in house dust (Cluster 1). High endotoxin level clustered with Alternaria and pet allergens in the homes of participants with a high socioeconomic status who own pets (Cluster 2) (48.9%). High endotoxin clustered with Aspergillus, dust mites, cockroach, and rodent allergens in the homes of participants with low socioeconomic status (Cluster 3) (33.3%). Compared to Cluster 1, Cluster 2 was associated with higher asthma prevalence (OR 1.42, 95% CI: 1.06-1.91) and wheeze (OR 1.32, 95% CI: 1.07-1.63). Cluster 3 was positively associated with wheeze only in participants sensitized to inhalant allergens (OR 1.42, 95% CI: 1.06-1.91) or exposed to tobacco smoke (OR 1.72, 95% CI: 1.15-2.60).
conclusionsThe clustering of endotoxin with allergens in dust from homes with pets or of people with low socioeconomic status is associated with asthma and wheeze.
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