ArticleBMC veterinary research2020
Leptospira infection and shedding in dogs in Thailand.
Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Emerging zoonotic diseases in Southeast Asia in the period 2011-2022: a systematic literature review.The veterinary quarterly · 2024Pooled it
- Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand.PLoS neglected tropical diseases · 2026Article
- Molecular surveillance of Leptospira infection in domestic dogs in Soledad, Northern Colombia.Veterinary research communications · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Seroprevalence of pathogenic leptospira in domiciled and stray dogs from subtropical Mexico.Veterinary research communications · 2025Article
- Risk Factors Associated with Azotemia in Dogs Presented to the Chiang Mai University Veterinary Teaching Hospital, Thailand: A Retrospective Study (2017-2021).Animals : an open access journal from MDPI · 2025Article
- FiveMicroorganisms · 2025Article
- Pet and Stray Dogs' Contribution to Zoonotic Transmission Pathways: A Bibliometric Review.Transboundary and emerging diseases · 2025Review
- Flood-associated disease outbreaks and transmission in Southeast Asia.Frontiers in microbiology · 2025Review
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- Survival outcomes, low awareness, and the challenge of neglected leptospirosis in dogs.Open veterinary journal · 2024Article
- Domestic dogs in indigenous Amazonian communities: Key players in Leptospira cycling and transmission?PLoS neglected tropical diseases · 2024Article
- Improved Antibody Detection for Canine Leptospirosis: ELISAs Modified Using Local Leptospiral Serovar Isolates from Asymptomatic Dogs.Animals : an open access journal from MDPI · 2024Article
- Leptospirosis and the Environment: A Review and Future Directions.Pathogens (Basel, Switzerland) · 2023Review
- Leptospiral Leucine-Rich Repeat Protein-Based Lateral Flow for Assessment of Canine Leptospiral Immunoglobulin G.Tropical medicine and infectious disease · 2022Article
- Potential Drivers for the Re-Emergence of Canine Leptospirosis in the United States and Canada.Tropical medicine and infectious disease · 2022Review
- Leptospira seroprevalence and associated risk factors in healthy Swedish dogs.BMC veterinary research · 2022Article
- Article
- High-level seroprevalence against Leptospira interrogans serovars among wild foxes, jackals and stray dogs in the North Khorasan Province, Iran.Veterinary medicine and science · 2022Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptospirosis is a widespread zoonosis and has been recognized as a re-emerging infectious disease in humans and dogs, but prevalence of Leptospira shedding in dogs in Thailand is unknown. The aim of this study was to determine urinary shedding of Leptospira in dogs in Thailand, to evaluate antibody prevalence by microscopic agglutination test (MAT) and enzyme-linked immunosorbent assay (ELISA), and to assess risk factors for Leptospira infection. In Northern, Northeastern, and Central Thailand, 273 stray (n = 119) or client-owned (n = 154) dogs from rural (n = 139) or urban (n = 134) areas were randomly included. Dogs that had received antibiotics within 4 weeks prior to sampling were excluded. No dog had received vaccination against Leptospira. Urine was evaluated by real-time polymerase chain reaction (PCR) specific for lipL32 gene of pathogenic Leptospira. Additionally, urine was cultured for 6 months in Ellinghausen-McCullough-Johnson-Harris (EMJH) medium. Antibodies were measured by ELISA and MAT against 24 serovars belonging to 15 serogroups and 1 undesignated serogroup. Risk factor analysis was performed with backwards stepwise selection based on Wald.
resultsTwelve of 273 (4.4%; 95% confidence interval (CI): 2.0-6.8%) urine samples were PCR-positive. In 1/273 dogs (0.4%; 95% CI: 0.01-1.1%) Leptospira could be cultured from urine. MAT detected antibodies in 33/273 dogs (12.1%; 95% CI: 8.2-16.0%) against 19 different serovars (Anhoa, Australis, Ballum, Bataviae, Bratislava, Broomi, Canicola, Copenhageni, Coxi, Grippotyphosa, Haemolytica, Icterohaemorrhagiae, Khorat, Paidjan, Patoc, Pyrogenes, Rachmati, Saxkoebing, Sejroe). In 111/252 dogs (44.0%; 95% CI: 37.9-50.2%) immunoglobulin M (IgM) and/or immunoglobulin G (IgG) antibodies were found by ELISA. Female dogs had a significantly higher risk for Leptospira infection (p = 0.023).
conclusionsLeptospira shedding occurs in randomly sampled dogs in Thailand, with infection rates comparable to those of Europe and the USA. Therefore, the potential zoonotic risk should not be underestimated and use of Leptospira vaccines are recommended.
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