Evidence map›Paper›PMID 32178459›Full record

ReviewInternational journal of molecular sciences2020

Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review.

Alberto Benussi, Alvaro Pascual-Leone, Barbara Borroni

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05625620 (A Long Term At-home Trial With Cerebellar-spinal Transcranial Pulsed Current Stimulation), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05625620 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Long Term At-home Trial With Cerebellar-spinal Transcranial Pulsed Current Stimulation (tPCS) for Treatment of Neurodegenerative Ataxia

TypeinterventionalSponsorWestern University, CanadaRan2023 to 2024Enrolled15ConditionsCerebellar AtaxiaArmsActive Transcranial Pulse Current Stimulation, Sham Transcranial Pulse Current Stimulation
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Repeated transcranial magnetic stimulation on the bilateral cerebellum to improve symptoms of ataxia with multiple system atrophy: a prospective, randomized, sham-controlled pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  12. Article
  13. Review
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  19. A Brief History of Cerebellar Neurostimulation.Cerebellum (London, England) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Alberto BenussiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Alvaro Pascual-LeoneArthur and Hinda Marcus Institute for Aging Brain, Hebrew SeniorLife and Department of Neurology, Harvard Medical School, Boston, MA 02131, USA.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
University of Brescia · ITHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar ataxias are a heterogenous group of degenerative disorders for which we currently lack effective and disease-modifying interventions. The field of non-invasive brain stimulation has made much progress in the development of specific stimulation protocols to modulate cerebellar excitability and try to restore the physiological activity of the cerebellum in patients with ataxia. In light of limited evidence-based pharmacologic and non-pharmacologic treatment options for patients with ataxia, several different non-invasive brain stimulation protocols have emerged, particularly employing repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) techniques. In this review, we summarize the most relevant rTMS and tDCS therapeutic trials and discuss their implications in the care of patients with degenerative ataxias.

Indexed as

Cerebellar AtaxiaCerebellumHumansTranscranial Direct Current StimulationTranscranial Magnetic Stimulationcerebellar ataxianeurodegenerative ataxianon-invasive brain stimulationtherapytranscranial direct current stimulationtranscranial magnetic stimulation

Identifiers

PMID32178459
PMCPMC7139863
OpenAlexW3011745538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.