Evidence map›Paper›PMID 32178409›Full record

ArticleInternational journal of molecular sciences2020

Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells.

Torsten Thalheim, Lydia Hopp, Maria Herberg, Susann Siebert, Christiane Kerner, Marianne Quaas, Michal R Schweiger, Gabriela Aust, Joerg Galle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Torsten ThalheimInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.ORCID 0000-0001-5489-7405
Lydia HoppInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.
Maria HerbergInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.
Susann SiebertLaboratory for Translational Epigenetics and Tumor Genetics, University Hospital Cologne, 50391 Cologne, Germany.
Christiane KernerDepartment of Surgery, Research Laboratories, Leipzig University, 04103 Leipzig, Germany.
Marianne QuaasDepartment of Surgery, Research Laboratories, Leipzig University, 04103 Leipzig, Germany.
Michal R SchweigerLaboratory for Translational Epigenetics and Tumor Genetics, University Hospital Cologne, 50391 Cologne, Germany.
Gabriela AustDepartment of Surgery, Research Laboratories, Leipzig University, 04103 Leipzig, Germany.
Joerg GalleInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, 04107 Leipzig, Germany.
Leipzig University · DEUniversity Hospital Cologne · DE

Funding

Bundesministerium für Bildung und Forschung 01ZX1304ABundesministerium für Bildung und Forschung 031A312Deutsche Forschungsgemeinschaft Clinical Research Unit KFO286Deutsche Forschungsgemeinschaft Collaborative Research Centre SFB1399Volkswagen Foundation Lichtenberg program
6 · The paper itself

Abstract

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates in DNA repair and that even successful DNA repair might confer this kind of epigenetic long-term change. Here, we ask for interrelations between promoter DNA methylation and histone modification changes observed in the intestine weeks after irradiation and/or following

Indexed as

AnimalsDNADNA MethylationEpigenesis, GeneticHistone CodeHistonesIntestinesMicePromoter Regions, GeneticStem CellsDNAhistone H3 trimethyl Lys4Histonescomputational modelingDNA damagehistone methylationirradiationloss of Msh2 functionpromoter DNA hyper-methylation

Identifiers

PMID32178409
PMCPMC7139626
OpenAlexW3011419785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.