ArticleGeriatrics (Basel, Switzerland)2020
Frailty Confers High Mortality Risk across Different Populations: Evidence from an Overview of Systematic Reviews and Meta-Analyses.
Article in Geriatrics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of the utility of the frailty index and frailty phenotype to predict all-cause mortality in older people.Systematic reviews · 2022Pooled it
- Enabling health and maintaining independence for older people at home: the 'HomeHealth' Randomised Controlled Trial.Health technology assessment (Winchester, England) · 2026Trial
- The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study.GeroScience · 2026Article
- Sitting Baduanjin Combined With Acupoint Massage on Frailty in Patients Undergoing Maintenance Hemodialysis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Identifying and Managing Frailty: A Survey of UK Healthcare Professionals.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- The Association between Functional Health Patterns and Frailty in Hospitalized Geriatric Patients.Geriatrics (Basel, Switzerland) · 2024Article
- Frailty transitions and prevalence in an ageing population: longitudinal analysis of primary care data from an open cohort of adults aged 50 and over in England, 2006-2017.Age and ageing · 2023Article
- Relationship between Lifestyle and Frailty among Iranian Community-Dwelling Older Adults: Pilot Study.JAR life · 2023Article
- Frailty status changes are associated with healthcare utilization and subsequent mortality in the elderly population.BMC public health · 2021Article
- Frailty Status and Polypharmacy Predict All-Cause Mortality in Community Dwelling Older Adults in Europe.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed an overview of systematic reviews and meta-analyses to summarize available data regarding the association between frailty and all-cause mortality. Medline, Embase, CINAHL, Web of Science, PsycINFO, and AMED (Allied and Complementary Medicine) databases were searched until February 2020 for meta-analyses examining the association between frailty and all-cause mortality. The AMSTAR2 checklist was used to evaluate methodological quality. Frailty exposure and the risk of all-cause mortality (hazard ratio [HR] or relative risk [RR]) were displayed in forest plots. We included 25 meta-analyses that pooled data from between 3 and 20 studies. The number of participants included in these meta-analyses ranged between <2000 and >500,000. Overall, 56%, 32%, and 12% of studies were rated as of moderate, low, and critically low quality, respectively. Frailty was associated with increased risk of all-cause mortality in 24/24 studies where the HR/RRs ranged from 1.35 [95% confidence interval (CI) 1.05-1.74] (patients with diabetes) to 7.95 [95% CI 4.88-12.96] (hospitalized patients). The median HR/RR across different meta-analyses was 1.98 (interquartile range 1.65-2.67). Pre-frailty was associated with a significantly increased risk of all-cause mortality in 7/7 studies with the HR/RR ranging from 1.09 to 3.65 (median 1.51, IQR 1.38-1.73). These data suggest that interventions to prevent frailty and pre-frailty are needed.
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