Evidence map›Paper›PMID 32178258›Full record

ArticleMolecules (Basel, Switzerland)2020

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase.

Simone Musiu, Yunierkis Perez Castillo, Alexandra Muigg, Gerhard Pürstinger, Pieter Leyssen, Mathy Froeyen, Johan Neyts, Jan Paeshuyse

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Simone MusiuKU Leuven University, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Yunierkis Perez CastilloBio-Cheminformatics Research Group and Escuela de Ciencias Físicas y Matemáticas, Universidad de Las Americas, 170150 Quito, Ecuador.ORCID 0000-0002-3710-0035
Alexandra MuiggInstitut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria.
Gerhard PürstingerInstitut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria.
Pieter LeyssenKU Leuven University, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Mathy FroeyenKU Leuven University, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Herestraat 49, B-3000 Leuven, Belgium mathy.froeyen@kuleuven.be.
Johan NeytsKU Leuven University, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Herestraat 49, B-3000 Leuven, Belgium.ORCID 0000-0002-0033-7514
Jan PaeshuyseKU Leuven, Division Animal and Human Health Engineering, Laboratory for host pathogen interactions, Kasteelpark Arenberg 30, 3001 Leuven, Belgium.ORCID 0000-0003-2396-354X
Rega Institute for Medical Research · BEUniversität Innsbruck · ATKU Leuven · BEUniversidad de Las Américas · EC

Funding

Belgian Federal Science Policy Office BELVIRKU Leuven GOA 10/14
6 · The paper itself

Abstract

The bovine viral diarrhea virus (BVDV), a pestivirus from the family of

Indexed as

AnimalsBovine Virus Diarrhea-Mucosal DiseaseCattleDiarrhea Viruses, Bovine ViralDrug Resistance, ViralMutationPestivirusQuinolinesVirus Replicationquinoline-4-carboxamideQuinolinesbovine viral diarrhea virusRNA-dependent RNA polymerasesubstituted quinolinecarboxamide inhibitors

Identifiers

PMID32178258
PMCPMC7144022
OpenAlexW3010977385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.