ArticleAngewandte Chemie (International ed. in English)2020
Unconventional Secondary Structure Mimics: Ladder-Rungs.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Review
- Computational profiling and virtual screening of MEK inhibitors for triple-negative breast cancer therapy.In silico pharmacology · 2025Article
- Turn-Mimic Hydantoin-Based Loops Constructed by a Sequential Multicomponent Reaction.The Journal of organic chemistry · 2023Article
- Synthesis and Conformational Analysis of Hydantoin-Based Universal Peptidomimetics.The Journal of organic chemistry · 2023Article
- Urokinase-type plasminogen activator receptor (uPAR) as a therapeutic target in cancer.Journal of translational medicine · 2022Review
- Piptides: New, Easily Accessible Chemotypes For Interactions With Biomolecules.Angewandte Chemie (International ed. in English) · 2021Article
- Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention.Frontiers in cell and developmental biology · 2021Review
- Small molecules targeting the NEDD8·NAE protein-protein interaction.Chemical science · 2020Article
- Proteomimetic surface fragments distinguish targets by function.Chemical science · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole chemotype (1) to protein-protein interfaces revealed it tends to align well across parallel and antiparallel sheets, like rungs on a ladder. One set of these overlays was observed for the protein-protein interaction uPA⋅uPAR. Consequently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface. Biophysical assays indicate these compounds did in fact bind uPAR, and elicit cellular responses that affected invasion, migration, and wound healing.
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Registered trials
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