Evidence map›Paper›PMID 32176496›Full record

ArticleJournal of the American Chemical Society2020

Electronic Conductance Resonance in Non-Redox-Active Proteins.

Bintian Zhang, Weisi Song, Jesse Brown, Robert Nemanich, Stuart Lindsay

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. DNA-Guided Robust Single-Protein Electronic Readout.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Conducting Atomic Force Microscopy of Protein Wires.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Article
  7. Electron transport through two interacting channels in Azurin-based solid-state junctions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Shallow conductance decay along theChemical science · 2024
    Article
  9. Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bintian ZhangBiodesign Institute, Arizona State University, Tempe, Arizona 87287, United States.
Weisi SongBiodesign Institute, Arizona State University, Tempe, Arizona 87287, United States.
Jesse BrownDepartment of Physics, Arizona State University, Tempe, Arizona 87287, United States.
Robert NemanichDepartment of Physics, Arizona State University, Tempe, Arizona 87287, United States.
Stuart LindsayBiodesign Institute, Arizona State University, Tempe, Arizona 87287, United States.ORCID 0000-0002-9364-6542

Funding

Instrument to Optimize DNA Sequencing by Recognition TunnelingR01HG006323 · NHGRI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LINDSAY, STUART · 2011 to 2015
$5.0M
Recognition Tunneling for Single Molecule RNA SequencingR01HG009180 · NHGRI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LINDSAY, STUART · 2016 to 2018
$1.8M
Conductance Fluctuations: A New Approach to Sequencing?R21HG010522 · NHGRI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LINDSAY, STUART · 2019 to 2020
$628k
NHGRI NIH HHS R01 HG006323NHGRI NIH HHS R01 HG009180NHGRI NIH HHS R21 HG010522
6 · The paper itself

Abstract

Bioelectronics research has mainly focused on redox-active proteins because of their role in biological charge transport. In these proteins, electronic conductance is a maximum when electrons are injected at the known redox potential of the protein. It has been shown recently that many non-redox-active proteins are good electronic conductors, though the mechanism of conduction is not yet understood. Here, we report single-molecule measurements of the conductance of three non-redox-active proteins, maintained under potential control in solution, as a function of electron injection energy. All three proteins show a conductance resonance at a potential ∼0.7 V removed from the nearest oxidation potential of their constituent amino acids. If this shift reflects a reduction of reorganization energy in the interior of the protein, it would account for the long-range conductance observed when carriers are injected into the interior of a protein.

Indexed as

BiotinElectric ConductivityElectrodesElectronicsElectronsElectron TransportModels, MolecularOxidation-ReductionProteinsStreptavidinBiotinProteinsStreptavidin

Identifiers

PMID32176496
PMCPMC7185870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.