Evidence map›Paper›PMID 32176474›Full record

ArticleACS combinatorial science2020

High-Throughput Experimentation and Continuous Flow Evaluation of Nucleophilic Aromatic Substitution Reactions.

Zinia Jaman, David L Logsdon, Botond Szilágyi, Tiago J P Sobreira, Deborah Aremu, Larisa Avramova, R Graham Cooks, David H Thompson

Abstract read
In one paragraph

Article in ACS combinatorial science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Advancement in Organic Synthesis through High Throughput Experimentation.Chemistry methods : new approaches to solving problems in chemistry · 2021
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zinia JamanDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.
David L LogsdonDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.
Botond SzilágyiDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100, United States.ORCID 0000-0001-7777-9612
Tiago J P SobreiraDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.
Deborah AremuDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.
Larisa AvramovaDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.
R Graham CooksDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-9581-9603
David H ThompsonDepartment of Chemistry, Purdue University, Bindley Bioscience Center, 1203 West State Street, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-0746-1526

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
NCI NIH HHS P30 CA023168
6 · The paper itself

Abstract

Nucleophilic aromatic substitution (S

Indexed as

Combinatorial Chemistry TechniquesHigh-Throughput Screening AssaysHydrocarbons, AromaticMolecular StructureSpectrometry, Mass, Electrospray IonizationHydrocarbons, AromaticDESI-MSdesorption electrospray ionization mass spectrometryflow chemistryhigh-throughput experimentationnucleophilic aromatic substitution

Identifiers

PMID32176474
PMCPMC12043022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.