ArticleCancer2020
An evolutionary framework for treating pediatric sarcomas.
Registry-linked trialAbstract read
In one paragraph
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06384404 (Functional Outcomes in Patients Who Undergo Upfront Surgical Resection for High-Grade Osteosarcoma of the Extremity), which is not on this map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional Outcomes in Patients Who Undergo Upfront Surgical Resection for High-Grade Osteosarcoma of the Extremity: A Pilot Study
Who cites it
33 citing papers in PubMed.
- Adaptive and sequential cancer therapies emerge from treatment schedule optimization.Research square · 2026Article
- Article
- Mathematical Oncology: How Modeling Is Transforming Clinical Decision-Making.Cancer research · 2025Review
- New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee.Pediatric blood & cancer · 2025Review
- Seclidemstat (SP-2577) Induces Transcriptomic Reprogramming and Cytotoxicity in Multiple Fusion-Positive Sarcomas.Cancer research communications · 2025Article
- Stackelberg Evolutionary Games of Cancer Treatment: What Treatment Strategy to Choose if Cancer Can be Stabilized?Dynamic games and applications · 2025Article
- Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis.Cancer letters · 2024Article
- Article
- Ecological and evolutionary dynamics to design and improve ovarian cancer treatment.Clinical and translational medicine · 2024Review
- Pediatric Leukemia Roadmaps Are a Guide for Positive Metastatic Bone Sarcoma Trials.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- An evolutionary differential game for regulating the role of monoclonal antibodies in treating signalling pathways in oesophageal cancer.Royal Society open science · 2024Article
- Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins.bioRxiv : the preprint server for biology · 2024Article
- A war on many fronts: cross disciplinary approaches for novel cancer treatment strategies.Frontiers in genetics · 2024Review
- The effect of tumor composition on the success of adaptive therapy: The case of metastatic Castrate-Resistant Prostate Cancer.PloS one · 2024Article
- Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy.Scientific reports · 2023Article
- Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.Cancer research · 2023Article
- Treatment of evolving cancers will require dynamic decision support.Annals of oncology : official journal of the European Society for Medical Oncology · 2023Review
- A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation.eLife · 2023Article
- Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Damon R ReedDepartment of Interdisciplinary Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-8238-2465
Jonathan MettsCancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St Petersburg, Florida.
Mariyah PressleyCancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Brooke L FridleyCancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Masanori HayashiDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Michael S IsakoffCenter for Cancer and Blood Disorders, Connecticut Children's Medical Center, Hartford, Connecticut.ORCID 0000-0003-4790-9919
David M LoebDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Rikesh MakanjiDiagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Ryan D RobertsDepartment of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0001-5028-744X
Matteo TruccoDepatment of Pediatrics, University of Miami, Miami, Florida.
Lars M WagnerDepartment of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Mark G AlexandrowCancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-4661-0368
Robert A GatenbyCancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Joel S BrownCancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2MThe Physi(ologi)cal Microenvironment and its Role in Tumor Invasion and MetastaseU54CA143970 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GATENBY, ROBERT A · 2009 to 2014
$9.3MElucidating and exploiting the mechanisms by which IL-6 and IL-8 facilitate osteosarcoma metastasisK08CA201638 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROBERTS, RYAN D. · 2016 to 2020
$815kNCI NIH HHS K08 CA201638NCI NIH HHS P30 CA013330NCI NIH HHS U54 CA143970
Abstract
PubMed holds no abstract for this paper.
Indexed as
Biological EvolutionBone NeoplasmsChildClinical Trials as TopicHumansModels, TheoreticalOsteosarcomaRhabdomyosarcomaSarcomaSarcoma, EwingSelection, Geneticadaptive therapyclinical trialevolutionEwing sarcomaextinction therapyfirst strikeosteosarcomaresistancerhabdomyosarcomasecond strike
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT06384404ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.