ArticleGenome biology and evolution2020
Significant Evolutionary Constraints on Neuron Cells Revealed by Single-Cell Transcriptomics.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 81 citations in OpenAlex.
- Neuron-specific homologous coding genes and non-coding regulatory regions are the most conserved amongst amniotes despite neuron-specific cell size diversity.Scientific reports · 2025Article
- BrainCellR: A precise cell type nomenclature pipeline for comparative analysis across brain single-cell datasets.Computational and structural biotechnology journal · 2024Article
- Functional Optimization in Distinct Tissues and Conditions Constrains the Rate of Protein Evolution.Molecular biology and evolution · 2024Article
- Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons.BMC biology · 2024Article
- Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons.bioRxiv : the preprint server for biology · 2024Article
- Convergence of the dysregulated regulome in schizophrenia with polygenic risk and evolutionarily constrained enhancers.Molecular psychiatry · 2024Article
- Role of caveolin-1 in metabolic programming of fetal brain.iScience · 2023Article
- scBrainMap: a landscape for cell types and associated genetic markers in the brain.Database : the journal of biological databases and curation · 2023Article
- Article
- Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective.Evolutionary human sciences · 2022Review
- Evolutionary conservation and divergence of the human brain transcriptome.Genome biology · 2021Article
- Genomics at cellular resolution: insights into cognitive disorders and their evolution.Human molecular genetics · 2020Review
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Recent advances in single-cell RNA-sequencing technology have enabled us to characterize a variety of different cell types in each brain region. However, the evolutionary differences among these cell types remain unclear. Here, we analyzed single-cell RNA-seq data of >280,000 cells and developmental transcriptomes of bulk brain tissues. At the single-cell level, we found that the evolutionary constraints on the cell types of different organs significantly overlap with each other and the transcriptome of neuron cells is one of the most restricted evolutionarily. In addition, mature neurons are under more constraints than neuron stem cells as well as nascent neurons and the order of the constraints of various cell types of the brain is largely conserved in different subregions. We also found that although functionally similar brain regions have comparable evolutionary constraints, the early fetal brain is the least constrained and this pattern is conserved in the mouse, macaque, and humans. These results demonstrate the importance of maintaining the plasticity of early brain development during evolution. The delineation of evolutionary differences between brain cell types has great potential for an improved understanding of the pathogenesis of neurological diseases and drug development efforts aimed at the manipulation of molecular activities at the single-cell level.
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