ArticleMedicine2020
Obesity is a risk factor for preoperative hypoxemia in Stanford A acute aortic dissection.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pooled it
- Impact of body mass index on perioperative mortality of acute stanford type A aortic dissection: a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- The association between body mass index and risk of preoperative oxygenation impairment in patients with the acute aortic syndrome.Frontiers in endocrinology · 2022Pooled it
- Construction of a Postoperative Complication Risk Model for Patients With Stanford Type A Aortic Dissection.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Systematic Review and Meta-analysis of Admission Inflammatory Biomarkers for Evaluating Prognosis in Acute Type A Aortic Dissection.Aorta (Stamford, Conn.) · 2025Article
- Analysis of risk factors for hypoxemia in PACU for patients undergoing thoracoscopic lung cancer resection based on logistic regression model.BMC anesthesiology · 2025Article
- Review
- Study on risk factors and treatment strategies of hypoxemia after acute type a aortic dissection surgery.Journal of cardiothoracic surgery · 2024Review
- Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection.Medicina (Kaunas, Lithuania) · 2024Article
- Postoperative hypoxemia for patients undergoing Stanford type A aortic dissection.World journal of clinical cases · 2023Review
- Acute Lung Injury in aortic dissection : new insights in anesthetic management strategies.Journal of cardiothoracic surgery · 2023Review
- Morbid obesity impacts mortality among inpatients with type a aortic dissection: an analysis of the national inpatient sample.Journal of cardiothoracic surgery · 2023Article
- Analysis of clinical characteristics and imagological features of the aortic dissection patients with negative D-dimer results.Frontiers in cardiovascular medicine · 2023Article
- Risk Factors for Aortic Dissection.US cardiology · 2023Review
- The relation of aortic dimensions and obesity in adults with Marfan or Loeys-Dietz syndrome.Cardiovascular diagnosis and therapy · 2022Article
- Differential expression profile of plasma exosomal microRNAs in acute type A aortic dissection with acute lung injury.Scientific reports · 2022Article
- Metabolic syndrome and its components are associated with hypoxemia after surgery for acute type A aortic dissection: an observational study.Journal of cardiothoracic surgery · 2022Observational
- Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection.BMC cardiovascular disorders · 2022Review
- Preoperative Nomogram and Risk Calculator for Postoperative Hypoxemia and Related Clinical Outcomes Following Stanford Type A Acute Aortic Dissection Surgery.Frontiers in cardiovascular medicine · 2022Article
- Factors Associated with Postoperative Lipiduria and Hypoxemia in Patients Undergoing Surgery for Orthopedic Fractures.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obese individuals are apt to develop Stanford A acute aortic dissection (AAD) complicated with acute lung injury (ALI), but the mechanism is still not well defined. We aim to investigate whether oxidative stress and inflammatory are involved in the aortic dissection lung injury caused by obesity.Seventy-nine patients were categorized into AAD with obesity group (n = 17) and AAD without obesity group (n = 62) according to body mass index (BMI). Inflammatory reactions including interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-6, C-reactive protein (CRP) and white blood cell (WBC) count, and oxidative stress including malondialdehyde (MDA), superoxide dismutase were determined using enzyme-linked immunosorbent assays and chemiluminescence. All the patients received ascending aorta replacement combined with total arch replacement and stented elephant trunk. The postoperative complications were recorded.The incidence of preoperative hypoxemia (94.1% vs 35.5%, P < .01) and postoperative ALI (88.2% vs 40.3%, P < .01) in obese patients was significantly higher than that in non-obese patients. Besides, the ICU stay (119.2 ± 59.2 vs 87.8 ± 31.2 h, P < .01) and hospitalization duration (18.8 ± 8.5 vs 14.3 ± 8.1d, P = .048) were increased in the obese patients with AAD. The expression of IL-1β, TNF-α, IL-6, CRP, and WBC was remarkably increased (P < .01) in obese group compared with non-obese group.Oxidative stress and inflammatory response may be involved in the process of ALI of aortic dissection caused by obesity, which provides new ideas for the treatment of ALI of the aortic dissection.
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Registered trials
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