ArticleeLife2020
PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Osteoblast-specific factor 2 reduces glutathione by downregulating PRKRA expression in oral squamous cell carcinoma.Translational cancer research · 2026Article
- Cellular osmoregulation enhances porcine embryo development by restoring zygotic genome activation via metabolic-epigenetic crosstalk.Cellular & molecular biology letters · 2025Article
- Article
- PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer.RNA (New York, N.Y.) · 2025Article
- IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections.PLoS pathogens · 2025Article
- PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration.Nature communications · 2025Article
- Direct ionic stress sensing and mitigation by the transcription factor NFAT5.Science advances · 2025Article
- Identifying Water-Salt Homeostasis and Inflammatory Response in Pathological Cardiac Surgery-Associated Acute Kidney Injury: NT-proBNP-related lncRNAs and miRNAs as Novel Diagnostic Biomarkers and Therapeutic Targets.International journal of medical sciences · 2025Article
- The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways.The EMBO journal · 2024Article
- Direct ionic stress sensing and mitigation by the transcription factor NFAT5.bioRxiv : the preprint server for biology · 2023Article
- Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress.Science advances · 2023Article
- PRKRA promotes pancreatic cancer progression by upregulating MMP1 transcription via the NF-κB pathway.Heliyon · 2023Article
- Luteolin protects DYT-Frontiers in pharmacology · 2023Article
- Activation of cytosolic RNA sensors by endogenous ligands: roles in disease pathogenesis.Frontiers in immunology · 2023Review
- Article
- dsRNA-induced condensation of antiviral proteins modulates PKR activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress.Communications biology · 2022Article
- Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.Cell reports · 2022Article
- Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations.RNA (New York, N.Y.) · 2022Review
- Untangling the roles of RNA helicases in antiviral innate immunity.PLoS pathogens · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 3 countries.
Kenneth T FarabaughDepartment of Pharmacology, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-9591-0466
Dawid KrokowskiDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Bo-Jhih GuanDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Zhaofeng GaoDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Xing-Huang GaoDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-0720-3690
Jing WuDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Raul JobavaDepartment of Biochemistry, Case Western Reserve University, Cleveland, United States.
Greeshma RayDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, United States.
Tristan J de JesusDepartment of Pathology, Case Western Reserve University, Cleveland, United States.
Massimiliano G BianchiDepartment of Medicine and Surgery, Universita degli Studi di Parma, Parma, Italy.
Evelyn ChukwurahDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.
Ovidio BussolatiDepartment of Medicine and Surgery, Universita degli Studi di Parma, Parma, Italy.ORCID 0000-0002-4301-2939
Michael KilbergDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, United States.
David A BuchnerDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0003-3920-4871
Ganes C SenDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, United States.
Calvin CottonDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, United States.
Christine McDonaldDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, United States.
Michelle LongworthDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, United States.
Parameswaran RamakrishnanDepartment of Pathology, Case Western Reserve University, Cleveland, United States.ORCID 0000-0002-1314-827X
Maria HatzoglouDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, United States.ORCID 0000-0003-2037-1231
Case Western Reserve University · USCleveland Clinic · USUniversity of Parma · ITMaria Curie-Skłodowska University · PLUniversity of Florida · US
Funding
TELOMERASE INACTIVATION BY RNASE L SIGNALS CELL DEATHP01CA062220 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOXIA, STARK, GEORGE ROBERT · 1994 to 2020
$35.6MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6MRegulation of Gene Expression During StressR01DK053307 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 1998 to 2021
$9.6MTranslational Control by NutrientsR01DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MARIA HATZOGLOU · 2002 to 2026
$6.3MSarcopenia in cirrhosis is mediated by a hyperammonemic stress responseR01DK113196 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI DASARATHY, SRINIVASAN, HATZOGLOU, MARIA · 2018 to 2021
$2.3MTranscriptional regulation by O-GlcNAcylation in T lymphocytesR01AI116730 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI RAMAKRISHNAN, PARAMESWARAN · 2016 to 2020
$2.0MRegulation of B cell function and antibody class switching by c-Rel O-GlcNAcylationR21AI144264 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI RAMAKRISHNAN, PARAMESWARAN · 2019 to 2020
$441kNCI NIH HHS P01 CA062220NIAID NIH HHS R01 AI116730NIAID NIH HHS R21 AI144264NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK053307NIDDK NIH HHS R01 DK060596NIDDK NIH HHS R01 DK113196
Abstract
The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostasis to inflammation, respectively. Here we identified PACT-mediated PKR kinase activation as a marker of the termination of adaptation and initiation of inflammation in
Indexed as
Osmotic PressureAdaptation, PhysiologicalAnimalsCarrier ProteinsCell LineeIF-2 KinaseGene Expression RegulationHumansMiceNF-kappa BProto-Oncogene Proteins c-relRNA-Binding ProteinsRNA InterferenceSignal TransductionCarrier ProteinsEIF2AK2 protein, humaneIF-2 KinaseNF-kappa BPRKRA protein, humanprotein kinase R, mouseProto-Oncogene Proteins c-relRbbp6 protein, mouseRNA-Binding ProteinsgeneticsgenomicsHyperosmotic stressimmunologyinflammationmouseNF-κB c-RelNF-κB p65PACTPKRTonEBP
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.