ArticleMovement disorders : official journal of the Movement Disorder Society2020
Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex.
Article in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Tremor modulation: a systematic review of resetting by single-pulse transcranial magnetic stimulation.Turkish journal of medical sciences · 2026Pooled it
- Clinical Effect on Cortical Reactivity of Theta Burst Versus High-Frequency Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease: A TMS-EEG Study.CNS neuroscience & therapeutics · 2025Trial
- Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Nonlinear dynamic genetic regulation identifies peripheral drivers of neurodegenerative disease progression.medRxiv : the preprint server for health sciences · 2026Article
- TMS-EEG signatures of motor network dysfunction in multiple sclerosis.Brain communications · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- The evolution of tremor in Parkinson's Disease: insights from a 4-year longitudinal assessment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Unraveling morphological brain network disparities Parkinsonian tremor from essential tremor: an artificial intelligence approach for clinical differentiation.NPJ Parkinson's disease · 2025Article
- Re-Emergent Vocal Tremor in a Patient with Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Influence of serotonin on the long-term muscle contraction of the Kohnstamm phenomenon.Scientific reports · 2025Article
- Oscillatory Coupling Between Thalamus, Cerebellum, and Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Non-invasive brain stimulation to modulate neural activity in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Association of motor subtype and tremor type with Parkinson's disease progression: An exploratory longitudinal analysis.Journal of Parkinson's disease · 2025Article
- Serotonin syndrome caused by escitalopram in Parkinson's disease psychosis: a case report.BMC geriatrics · 2024Article
- The digital signature of emergent tremor in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Resting and re-emergent jaw tremor as the presenting symptom of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- The role of laboratory investigations in the classification of tremors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Physiological Recordings of the Cerebellum in Movement Disorders.Cerebellum (London, England) · 2023Review
- Distal Upper Limb Tremor during Walking in Parkinson's Disease.Movement disorders clinical practice · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundParkinson's disease patients may show a tremor that appears after a variable delay while the arms are kept outstretched (re-emergent tremor). The objectives of this study were to investigate re-emergent tremor pathophysiology by studying the role of the primary motor cortex in this tremor and making a comparison with rest tremor.
methodsWe enrolled 10 Parkinson's disease patients with both re-emergent and rest tremor. Tremor was assessed by spectral analysis, corticomuscular coherence and tremor-resetting produced by transcranial magnetic stimulation over the primary motor cortex. We also recorded transcranial magnetic stimulation-evoked potentials generated by motor cortex stimulation during rest tremor, tremor suppression during wrist extension, and re-emergent tremor. Spectral analysis, corticomuscular coherence, and tremor resetting were compared between re-emergent tremor and rest tremor.
resultsRe-emergent tremor showed significant corticomuscular coherence, causal relation between motor cortex activity and tremor muscle and tremor resetting. The P60 component of transcranial magnetic stimulation-evoked potentials reduced in amplitude during tremor suppression, recovered before re-emergent tremor, was facilitated at re-emergent tremor onset, and returned to values similar to those of rest tremor during re-emergent tremor. Compared with rest tremor, re-emergent tremor showed similar corticomuscular coherence and tremor resetting, but slightly higher frequency.
conclusionsRe-emergent tremor is causally related with the activity of the primary motor cortex, which is likely a convergence node in the network that generates re-emergent tremor. Re-emergent tremor and rest tremor share common pathophysiological mechanisms in which the motor cortex plays a crucial role. © 2020 International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.