Evidence map›Paper›PMID 32175522›Full record

ArticleGeneral psychiatry2020

Altered heartbeat perception sensitivity associated with brain structural alterations in generalised anxiety disorder.

Hui Li, Bin Zhang, Qiang Hu, Lanlan Zhang, Yi Jin, Jijun Wang, Huiru Cui, Jiaoyan Pang, Chunbo Li

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in General psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Identifying and managing functional cardiac symptoms.Clinical medicine (London, England) · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hui Li *Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bin Zhang *Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
Qiang HuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lanlan ZhangDepartment of Psychiatry, Suzhou Guangji Hospital, Suzhou, China.
Yi JinInstitute of Psychology, Chinese Academy of Sciences, Shanghai, China.
Jijun WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huiru CuiShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiaoyan PangDepartment of Psychology, Shanghai University of Political Science and Law, Shanghai, China.
Chunbo LiShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNGuangzhou Medical University · CNInstitute of Psychology, Chinese Academy of Sciences · CNShanghai University of Political Science and Law · CNSuzhou Guangji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPalpitation is a common complaint in generalised anxiety disorder (GAD). Brain imaging studies have investigated the neural mechanism of heartbeat perception in healthy volunteers. This study explored the neuroanatomical differences of altered heartbeat perception in patients with GAD using structural MRI.

aimsBased on the strong somatic-interoceptive symptoms in GAD, we explored the regional structural brain abnormalities involved in heartbeat perception in patients with GAD.

methodsThis study was applied to the a priori regions using neuroanatomical theories of heartbeat perception, including the insula, anterior cingulate cortex, supplementary motor area and prefrontal cortex. A total of 19 patients with GAD and 19 healthy control subjects were enrolled. We used the FMRIB Software Library voxel-based morphometry software for estimating the grey matter volume of these regions of interest and analysed the correlation between heartbeat perception sensitivity and the volume of abnormal grey matter.

resultsPatients with GAD showed a significantly decreased volume of grey matter in their left medial prefrontal cortex, right orbital frontal cortex and anterior cingulate cortex. The grey matter volume of the left medial prefrontal cortex negatively correlated with heartbeat perception sensitivity in patients with GAD.

conclusionsIt should be the first study that shows heartbeat perception is associated with brain structure in GAD. Our findings suggest that the frontal region may play an important role in aberrant heartbeat perception processing in patients with GAD, and this may be an underlying mechanism resulting in the abnormal cardiovascular complaints in GAD. This is hypothesised as a 'top-down' deficiency, especially in the medial prefrontal cortex. This will provide the foundation for a more targeted region for neuromodulation intervention in the future.

Indexed as

generalised anxiety disordergrey matter volumeheartbeat perception sensitivitymedial prefrontal cortexstructural MRI

Identifiers

PMID32175522
PMCPMC7047474
OpenAlexW3005807893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.