ArticleEye and vision (London, England)2020
Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy.
Article in Eye and vision (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Optical coherence tomography angiography in thyroid associated ophthalmopathy: a systematic review.BMC ophthalmology · 2024Pooled it
- OCT and OCTA in dysthyroid optic neuropathy: a systematic review and meta-analysis.BMJ open ophthalmology · 2023Pooled it
- Current insights of applying MRI in Graves' ophthalmopathy.Frontiers in endocrinology · 2022Pooled it
- Combined use of orbital soft tissue volume and retinal microvessel density for diagnosing dysthyroid optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Ocular Hypertension and Glaucoma in Graves' Orbitopathy: A Single-Center Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Quantitative Analysis of Choroidal Thickness and Blood Flow in Thyroid-Associated Ophthalmopathy Using Ultra-Widefield Swept-Source OCT Angiography.Ophthalmology science · 2026Article
- OptiDON-Guard: An Ensemble Model for Identification of Dysthyroid Optic Neuropathy Using Optical Coherence Tomography Angiography.Translational vision science & technology · 2026Article
- Article
- Quadrant asymmetry alteration of retinal degeneration in thyroid-associated ophthalmopathy.Journal of translational medicine · 2025Article
- Effects of pulse glucocorticoid treatment on retinal blood flow in patients with active Graves' orbitopathy.BMC ophthalmology · 2025Article
- Spectral-domain optical coherence tomography imaging findings in patients receiving teprotumumab for thyroid eye disease.American journal of ophthalmology case reports · 2025Article
- Retinal and Choroidal Alterations in Thyroid-Associated Ophthalmopathy: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Increased choroidal stromal area in patients with active Graves' ophthalmopathy based on binarisation method of optical coherence tomographic images.BMJ open ophthalmology · 2024Article
- Optic nerve compression associated with visual cortex functional alteration in dysthyroid optic neuropathy: A combined orbital and brain imaging study.CNS neuroscience & therapeutics · 2024Article
- Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST.Ophthalmology and therapy · 2024Article
- Changes in retinal nerve fibre layer, ganglion cell layer and visual function in eyes with thyroid eye disease of different severities with and without orbital decompression.Eye (London, England) · 2023Article
- Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy.Eye and vision (London, England) · 2023Article
- Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema.Frontiers in endocrinology · 2023Article
- Assessment of Choroidal Vascularity in Inactive Thyroid Associated Orbitopathy.Beyoglu eye journal · 2023Article
- Ganglion cell layer thickness - a marker for early dysthyroid optic neuropathy.Eye (London, England) · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe goal was to investigate changes of the inner intra-retinal layer thicknesses and retinal capillary density (RCD) around the macula in thyroid-associated ophthalmopathy (TAO) patients with or without dysthyroid optic neuropathy (DON).
methodsForty-four TAO patients including 23 non-DON and 21 DON patients, and 38 healthy participants were enrolled. Spectral domain optical coherence tomography equipped with Angiovue was used to obtain three-dimensional retinal thickness maps and microvascular images of the superficial and deep retinal capillary layers (SRCL and DRCL, respectively) around the macula. Quantitative analyses were performed using a custom automated algorithm.
resultsThe thicknesses of the nerve fiber layer, ganglion cell layer + inner plexiform layer, and ganglion cell complex (GCC) as well as the RCDs in the SRCL and DRCL in both TAO groups were significantly decreased compared to the controls. In addition, the RCDs in DRCL of the DON group were further decreased compared to the non-DON group. GCC thickness in both TAO groups was positively correlated with the RCDs of the SRCL in the total annular zone and in the temporal, inferior, and nasal sectors. The areas under the receiver operating characteristic curves for the GCC thickness combined with the RCD were generally larger than those of each single indicator.
conclusionsThinned inner intra-retinal layers and decreased RCDs in the TAO patients without DON revealed that morphological changes might precede visual dysfunction. The composite index of the retinal structure and the microvascular density might be valuable in the diagnosing, monitoring, and intervention for early DON.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.