ArticleFrontiers in bioengineering and biotechnology2020
Impact of Aortoseptal Angle Abnormalities and Discrete Subaortic Stenosis on Left-Ventricular Outflow Tract Hemodynamics: Preliminary Computational Assessment.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Discrete subaortic stenosis: prognostic value of the left ventricular outflow tract gradient and implications for earlier surgical intervention.World journal of pediatrics : WJP · 2026Article
- Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells.Annals of biomedical engineering · 2026Article
- Aorto-septal Angle as a Predictor of Left Ventricular Outflow Tract Obstruction in Pediatric Patients With Subaortic Stenosis and Subaortic Membrane Development: A Study at Prince Sultan Cardiac Center, Buraydah, Saudi Arabia 2023.Journal of the Saudi Heart Association · 2025Article
- Assessment of the Aorto-Septal Angle Post-Thoracic Endovascular Aortic Repair through Segmentation and the Semi-Automatic Analysis of Cardiosynchronized Computed Tomography Angiography Images.Journal of cardiovascular development and disease · 2024Article
- Isolation and Characterization of Porcine Endocardial Endothelial Cells.Tissue engineering. Part C, Methods · 2023Article
- Hemodynamic Effects of Subaortic Stenosis on Blood Flow Characteristics of a Mechanical Heart Valve Based on OpenFOAM Simulation.Bioengineering (Basel, Switzerland) · 2023Article
- Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study.Computers in biology and medicine · 2022Article
- Current state of the art in hypoplastic left heart syndrome.Frontiers in cardiovascular medicine · 2022Review
- Evaluation of hemodynamic effects of different inferior vena cava filter heads using computational fluid dynamics.Frontiers in bioengineering and biotechnology · 2022Article
- Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study.Cardiovascular engineering and technology · 2021Article
- The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease.Frontiers in cardiovascular medicine · 2021Review
- The Anastomotic Angle of Hemodialysis Arteriovenous Fistula Is Associated With Flow Disturbance at the Venous Stenosis Location on Angiography.Frontiers in bioengineering and biotechnology · 2020Article
- Hemodynamic Analysis of VenaTech Convertible Vena Cava Filter Using Computational Fluid Dynamics.Frontiers in bioengineering and biotechnology · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Discrete subaortic stenosis (DSS) is an obstruction of the left ventricular outflow tract (LVOT) due to the formation of a fibromuscular membrane upstream of the aortic valve. DSS is a major risk factor for aortic regurgitation (AR), which often persists after surgical resection of the membrane. While the etiology of DSS and secondary AR is largely unknown, the frequent association between DSS and aortoseptal angle (AoSA) abnormalities has supported the emergence of a mechanobiological pathway by which hemodynamic stress alterations on the septal wall could trigger a biological cascade leading to fibrosis and membrane formation. The resulting LVOT flow disturbances could activate the valve endothelium and contribute to AR. In an effort to assess this hypothetical mechano-etiology, this study aimed at isolating computationally the effects of AoSA abnormalities on septal wall shear stress (WSS), and the impact of DSS on LVOT hemodynamics. Two-dimensional computational fluid dynamics models featuring a normal AoSA (N-LV), a steep AoSA (S-LV), and a steep AoSA with a DSS lesion (DSS-LV) were designed to compute the flow in patient-specific left ventricles (LVs). Boundary conditions consisted of transient velocity profiles at the mitral inlet and LVOT outlet, and patient-specific LV wall motion. The deformation of the DSS lesion was computed using a two-way fluid-structure interaction modeling strategy. Turbulence was accounted for via implementation of the
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