ReviewBiomedical engineering letters2020
The state of the art of osseointegration for limb prosthesis.
Review in Biomedical engineering letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Effective Interventions in Restoring Mobility and Relieving Pain After Lower Limb Amputation.Journal of orthopaedics and sports medicine · 2026Article
- Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.Journal of biomedical materials research. Part A · 2026Review
- Monitoring the Residual Limb-Socket Interface: A Perspective on Clinical Needs and Challenges.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Altered cumulative joint moments and increased joint moment symmetry during sit-to-stand transitions for transfemoral bone-anchored limb users: A case series.Clinical biomechanics (Bristol, Avon) · 2025Article
- Breaking Barriers-The Promise and Challenges of Limb Osseointegration Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Keratin Additive for Cellular Adhesion in Transcutaneous Prosthetics.Journal of tissue engineering and regenerative medicine · 2025Article
- Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.Advanced healthcare materials · 2024Review
- Harmonic Vibration Analysis in a Simplified Model for Monitoring Transfemoral Implant Loosening.Sensors (Basel, Switzerland) · 2024Article
- New materials and complications of prostheses in humans: situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Review
- Comparison In Vitro Study on the Interface between Skin and Bone Cell Cultures and Microporous Titanium Samples Manufactured with 3D Printing Technology Versus Sintered Samples.Nanomaterials (Basel, Switzerland) · 2024Article
- Advantages of customization of osseointegrated implants in transfemoral amputees: a comparative analysis of surgical planning.Journal of orthopaedic surgery and research · 2024Article
- Emerging Value of Osseointegration for Intuitive Prosthetic Control after Transhumeral Amputations: A Systematic Review.Plastic and reconstructive surgery. Global open · 2024Article
- Soft robotics in wearable and implantable medical applications: Translational challenges and future outlooks.Frontiers in robotics and AI · 2023Article
- An antimicrobial blue light device to manage infection at the skin-implant interface of percutaneous osseointegrated implants.PloS one · 2023Article
- Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance "epithelial barrier structure" formation via FN-ITG β1-FAK-mTOR signaling cascade.Biomaterials research · 2022Article
- Osseointegration for Lower-Extremity Amputees: Operative Considerations from the Plastic Surgeon's Perspective.JBJS reviews · 2022Article
- Determining the Antibiofilm Efficacy of Oregano Gel in an Ex Vivo Model of Percutaneous Osseointegrated Implants.Microorganisms · 2022Article
- Fifty years of bone tumors.Journal of surgical oncology · 2022Article
- Implantable biosensors for musculoskeletal health.Connective tissue research · 2022Review
- Optimising soft tissue in-growthBiomaterials translational · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osseointegration (OI) is the direct attachment of bone onto a titanium implant. Recently, the term is used to describe "transdermal" implants that allow an external prosthesis to be connected directly to the skeleton. This technology eliminates the challenges of conventional socket-based prostheses, such as skin breakdown and poor fit, which are common in patients with major extremity amputations. Osseointegration patients demonstrate encouraging improvements in quality of life and function. Patients report improvement in prosthetic use, prosthetic mobility, global health, and pain reduction on a variety of clinical assessment tools. Various implants have been developed for osseointegration for amputees. These implants use a variety of fixation strategies and surface augments to allow for successful integration into the host bone. Regardless of design, all OI implants face similar challenges, particularly infections. Other challenges include the inability to determine when integration has occurred and the inability to detect loss of integration. These challenges may be met by incorporating sensing systems into the implants. The percutaneous nature of the metal devices can be leveraged so that internal sensors need not be wireless, and can be interrogated by external monitoring systems, thus providing crucial, real-time information about the state of the implant. The purpose of this review is to (1) review the basic science behind osseointegration, (2) provide an overview of current implants, practice patterns, and clinical outcomes, and (3) preview sensor technologies which may prove useful in future generations of transdermal orthopaedic implants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.