ArticleJournal of gastrointestinal oncology2020
Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases.
Article in Journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Trends and Outcomes of the Liver-First Surgical Approach for Patients with Colorectal Cancer and Isolated Liver Metastases.Annals of surgical oncology · 2026Article
- Stage IV and recurrent colorectal cancer cured following multimodal therapy: A case series.Oncology letters · 2024Article
- Neoadjuvant Versus Adjuvant Chemotherapy for Resectable Metastatic Colon Cancer in Non-academic and Academic Programs.The oncologist · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe only possibility for cure in patients with colon adenocarcinoma (CAC) with isolated liver metastases (ILM) is resection of both primary and metastatic tumors. Little is known about the implication of the sequence in which a colectomy and hepatectomy are performed on outcomes. This study analyzes whether resection sequence impacts clinical outcomes.
methodsThe National Cancer Database was queried for CAC cases with hepatic metastases from 2010-2015 with exclusion of extrahepatic metastases. We compared patients treated with a liver-first approach (LFA) to those treated with a colectomy-first or simultaneous approach using Kaplan Meier and multivariable Cox proportional hazards analysis.
resultsIn 21,788 CAC patients identified, the LFA was uncommon (2%), but was associated with higher rates of completion resection of remaining tumor (41%
conclusionsThe LFA to CAC with synchronous ILM is uncommon but is associated with greater likelihood of receiving chemotherapy prior to surgery and increased survival in selected candidates.
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