Evidence map›Paper›PMID 32175090›Full record

ArticleJournal of virus eradication2020

A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.

Michael J Peluso, Lynda Dee, Danielle Campbell, Jeff Taylor, Rebecca Hoh, Rachel L Rutishauser, John Sauceda, Steven G Deeks, Karine Dubé

Abstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael J PelusoDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lynda DeeAIDS Action Baltimore, Baltimore, MD, USA.
Danielle CampbellamfAR Institute for HIV Cure Research Community Advisory Board, USA.
Jeff TayloramfAR Institute for HIV Cure Research Community Advisory Board, USA.
Rebecca HohDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Rachel L RutishauserDivision of Experimental Medicine, UCSF, San Francisco, CA, USA.
John SaucedaCenter for AIDS Prevention Studies, UCSF, San Francisco, CA, USA.
Steven G DeeksDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
Karine DubéUNC Gillings School of Global Public Health, Chapel Hill, NC, USA.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
Dissecting the signals that maintain HIV-specific CD8+ T cell exhaustion - administrative supplementK23AI134327 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUTISHAUSER, RACHEL LENA · 2018 to 2022
$1.1M
NIAID NIH HHS K23 AI134327NIAID NIH HHS P30 AI027763NIAID NIH HHS T32 AI060530NIAID NIH HHS UM1 AI126611NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres.

Indexed as

analytical treatment interruptionHIVHIV cure researchHIV remission research

Identifiers

PMID32175090
PMCPMC7043899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.