Evidence map›Paper›PMID 32175085›Full record

ArticleJournal of virus eradication2020

Feasibility and safety of research sigmoid colon biopsy in a cohort of Thai men who have sex with men with acute HIV-1.

Michelle Chintanaphol, Carlo Sacdalan, Suteeraporn Pinyakorn, Rungsun Rerknimitr, Wiriyaporn Ridtitid, Piyapan Prueksapanich, Irini Sereti, Alexandra Schuetz, Trevor A Crowell, Donn J Colby and 5 more

Open access · goldAbstract readEditorial
PubMed Full text at PMC
In one paragraph

Article in Journal of virus eradication, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Michelle ChintanapholDepartment of Neurology, Yale University, New Haven, CT, USA.
Carlo SacdalanSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Suteeraporn PinyakornUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Rungsun RerknimitrDepartment of Medicine, Gastroenterology, Chulalongkorn University, Bangkok, Thailand.
Wiriyaporn RidtitidDepartment of Medicine, Gastroenterology, Chulalongkorn University, Bangkok, Thailand.
Piyapan PrueksapanichDepartment of Medicine, Gastroenterology, Chulalongkorn University, Bangkok, Thailand.
Irini SeretiLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
Alexandra SchuetzUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Trevor A CrowellUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Donn J ColbySEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Merlin L RobbUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nittaya PhanuphakSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Jintanat AnanworanichSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Serena S SpudichDepartment of Neurology, Yale University, New Haven, CT, USA.
Eugène KroonSEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Thai Red Cross Society · THChulalongkorn University · THWalter Reed Army Institute of Research · USYale University · USArmed Forces Research Institute of Medical Science · THHenry M. Jackson Foundation · USNational Institute of Allergy and Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gut-associated lymphoid tissue (GALT) is a major reservoir of HIV-1 established early in acute HIV-1 infection (AHI). Sampling tissue from GALT can provide information about viral reservoirs and immune responses but may be complicated during AHI for reasons such as high viral replication, CD4 T cell depletion and immune activation. Risk of adverse events (AEs) associated with research sigmoid colon biopsies was assessed in participants with AHI in Bangkok, Thailand.

methodsBetween 2009 and 2016, 170 biopsies collected from the sigmoid colon were performed during AHI and at follow-up visits (median 24 weeks post AHI diagnosis). Adverse event incidence was evaluated, as well as the associations of procedure timing, repetition and clinical parameters with AE risk. Negative binomial regression models were used to calculate incidence rate ratios and 95% confidence intervals.

resultsAmong 103 participants (median age of 27 years, 97.1% male, 96.1% men who have sex with men), 87 sigmoidoscopies were completed during AHI and 83 at a follow-up visit. Approximately 30 biopsies were obtained per procedure for assessment of colonic viral load and HIV-1 reservoir, immunohistochemistry or phenotypic assays. All 11 AEs were grade 1 (6.5%) and included abdominal discomfort (

conclusionsComplications of sigmoidoscopy with biopsy in participants with AHI were infrequent and mild. Longitudinal sampling of the sigmoid colon to evaluate the gut-associated HIV-1 reservoir can be safely performed as part of research studies.

Indexed as

acute HIV-1 infectioncolon biopsyresearch risk

Identifiers

PMID32175085
PMCPMC7043900
OpenAlexW3012773697

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.