Evidence map›Paper›PMID 32175006›Full record

ArticleChild and adolescent psychiatry and mental health2020

Medications for sleep disturbance in children and adolescents with depression: a survey of Canadian child and adolescent psychiatrists.

Addo Boafo, Stephanie Greenham, Marla Sullivan, Khalid Bazaid, Sinthuja Suntharalingam, Lana Silbernagel, Katherine Magner, Rébecca Robillard

Open access · goldAbstract read
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Images: Pharmacological treatment of pediatric insomnia: a successful trial of doxepin.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  3. Quetiapine and Paediatric Psychiatrica:Psychopharmacology bulletin · 2025
    Review
  4. Article
  5. The Pathogenesis and Treatment of Insomnia Combined with Depression.International journal of general medicine · 2025
    Review
  6. Article
  7. Article
  8. [Overview of chronobiological and sleep medical aspects of depression in adolescents].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024
    Review
  9. Review
  10. Article
  11. Poor Sleep Quality in Aging: The Association with Mental Health.International journal of environmental research and public health · 2023
    Article
  12. Common Issues for General Practitioners in the Medical Management of Child and Adolescent Psychiatric Care.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023
    Article
  13. Article
  14. Diagnosis and management of sleep disorders in Prader-Willi syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Review
  15. Article
  16. Trazodone Prescribing for Children With Attention Deficit Hyperactivity Disorder on Medicaid in Oregon.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Addo Boafo1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.ORCID 0000-0001-6406-3682
Stephanie Greenham1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.
Marla Sullivan1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.
Khalid Bazaid1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.
Sinthuja Suntharalingam1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.
Lana Silbernagel2Department of Psychiatry, University of Ottawa, Ottawa, ON Canada.
Katherine Magner1Mental Health Program, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON KH 8L1 Canada.
Rébecca RobillardSleep Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON Canada.
University of Ottawa · CAChildren's Hospital of Eastern Ontario · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary care physicians and child and adolescent psychiatrists often treat sleep disturbances in children and adolescents with mood disorders using medications off-label, in the absence of clear evidence for efficacy, tolerability and short or long-term safety. This study is the first to report Canadian data about prescribing preferences and perceived effectiveness reported by child and adolescent psychiatrists regarding medications used to manage sleep disturbances in children and adolescents with depression.

methodsCanadian child and adolescent psychiatrists were surveyed on their perception of effectiveness of a range of medications commonly prescribed for sleep disturbances, their ranked preferences for these medications, reasons for avoiding certain medications, and perceived side effects.

resultsSixty-seven active child and adolescent psychiatrists completed the survey. Respondents reported noting significant sleep issues in 40% of all their patients. Melatonin and trazodone were identified as the first treatment of choice by 83% and 10% of respondents respectively, and trazodone was identified as the second treatment of choice by 56% of respondents for treating sleep disturbances in children and adolescents with depression. Melatonin (97%), trazodone (81%), and quetiapine (73%) were rated by a majority of respondents as effective. Doxepin, zaleplon, tricyclic antidepressants, zolpidem, or lorazepam were rarely prescribed due to lack of evidence and/or concerns about adverse effects, long-term safety, suitability for youth, suicidality, and dependence/tolerance.

conclusionsMelatonin and certain off-label psychotropic drugs are perceived as being more effective and appropriate to address sleep disturbances in children and adolescents with depression. More empirical evidence on the efficacy, tolerability and indications for using these medications and newer group of sleep medications in this population is needed.

Indexed as

AdolescentsChildrenDepressionSleep medications

Identifiers

PMID32175006
PMCPMC7063733
OpenAlexW3010698682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.