ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2020
Does primary tumor resection contribute to overall survival in unresectable synchronous metastatic colorectal cancer?
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Relationship Between MUC4 Variants and Metastatic Recurrence in Colorectal Cancer.International journal of general medicine · 2023Article
- Does chronic kidney disease affect the complications and prognosis of patients after primary colorectal cancer surgery?World journal of gastrointestinal oncology · 2022Article
- The role of upfront primary tumor resection in asymptomatic patients with unresectable stage IV colorectal cancer: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- Article
- Primary tumor resection benefited the survival of patients with distant metastatic gastric cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Specific causes of recurrence after surgery and mortality in patients with colorectal cancer: A competing risks survival analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Efficacy of Primary Tumor Resection in Metastatic Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary tumor resection (PTR) in metastatic colorectal cancer (mCRC) has not been suggested by guidelines, since new systemic chemotherapy options have improved overall survival. However, the effect of PTR is still controversial in mCRC. In this study, we aimed to evaluate the effect of PTR on survival in unresectable mCRC. MATERIALS AND
methodsTwo hundred and fifty-two patients with unresectable mCRC were screened retrospectively between January 2007 and December 2017 and a total of 147 patients who met inclusion criteria were included. The patients with emergency or elective PTR and the patients without surgery were compared for baseline features and overall survival.
resultsThe median follow-up time was 15.6 months (range; 1.2-78.9) in whole patients. There were 91 patients in nonsurgical (NS) group and 56 patients in PTR group. The median overall survival was significantly longer in PTR group compared NS group (21.8 vs. 17.0 months,
conclusionPTR did not offer an overall survival benefit in this study. Although it is debated, we think that it is better to start treatment with chemotherapy and biological agent combinations in patients with asymptomatic mCRC. Thus, the patients can be protected from the morbidity and mortality of the surgery.
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