Evidence map›Paper›PMID 32174922›Full record

ReviewFrontiers in immunology2020

The Crosstalk Between Hippo-YAP Pathway and Innate Immunity.

Shuai Wang, Lili Zhou, Li Ling, Xuli Meng, Feng Chu, Suping Zhang, Fangfang Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Hippo/YAP signaling's multifaceted crosstalk in cancer.Frontiers in cell and developmental biology · 2025
    Review
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shuai WangInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Lili ZhouInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Li LingInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Xuli MengDepartment of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Feng ChuInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Suping ZhangGuangdong Key Laboratory for Genome Stability and Human Disease Prevention, Department of Pharmacology, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.
Fangfang ZhouInstitutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Soochow University · CNShenzhen University Health Science Center · CNZhejiang Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. Hippo-YAP pathway regulates cell proliferation, survival, differentiation and is involved in diverse life processes, including tissue homeostasis and tumor suppression. Emerging discoveries elucidated that the components of Hippo-YAP pathway, such as MST1/2, NDR1/2, and YAP/TAZ played crucial regulatory roles in innate immunity. Meanwhile the innate immune signaling also exhibited regulatory effect on Hippo-YAP pathway. As for the importance of these two pathways, it would be interesting to figure out the deeper biological implications of their interplays. This review focuses on the regulation between Hippo-YAP pathway and innate immune signaling. We also propose the possible contribution of these interplays to tumor development.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsHippo Signaling PathwayHumansImmunity, InnateInflammationInterferon Type INeoplasmsNF-kappa BProtein Serine-Threonine KinasesReactive Oxygen SpeciesSignal TransductionTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingInterferon Type IMAP4K3 protein, humanNF-kappa BProtein Serine-Threonine KinasesReactive Oxygen SpeciesSTK38 protein, humanTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsHippo-YAP pathwayinnate immunityNF-kB signalingtumor developmenttype I interferon

Identifiers

PMID32174922
PMCPMC7056731
OpenAlexW3007012676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.