ArticleFrontiers in psychiatry2020
Functional Status of Hypothalamic-Pituitary-Thyroid and Hypothalamic-Pituitary-Adrenal Axes in Hospitalized Schizophrenics in Shanghai.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pineal Gland Volume, Sleep Quality, and Psychiatric Disorders: A Systematic Review and Meta-Analysis.Acta psychiatrica Scandinavica · 2026Pooled it
- Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets.Computational and mathematical methods in medicine · 2022Trial
- Thyroid hormones and cognitive function in chronic schizophrenia: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.Annals of general psychiatry · 2025Article
- Disease duration-stratified associations of thyroid hormone levels with psychopathology in hospitalized patients with schizophrenia: A cross-sectional study.World journal of psychiatry · 2025Article
- Is There a Link Between TSH Levels and Schizophrenia? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms.World journal of psychiatry · 2025Article
- Redefining the Cut-Off Ranges for TSH Based on the Clinical Picture, Results of Neuroimaging and Laboratory Tests in Unsupervised Cluster Analysis as Individualized Diagnosis of Early Schizophrenia.Journal of personalized medicine · 2022Article
- Biochemical and Endocrine Parameters for the Discrimination and Calibration of Bipolar Disorder or Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Hypothalamic-Pituitary-End-Organ Axes: Hormone Function in Female Patients with Major Depressive Disorder.Neuroscience bulletin · 2021Review
- A retrospective study of pituitary-thyroid interaction in patients with first-episode of bipolar disorder type I in Mania State.Medicine · 2021Article
- Associations of C-Reactive Protein, Free Triiodothyronine, Thyroid Stimulating Hormone and Creatinine Levels with Agitation in Patients with Schizophrenia: A Comparative Cross-Sectional Study.Neuropsychiatric disease and treatment · 2021Article
- The Relationship of Functional Status of Cortisol, Testosterone, and Parameters of Metabolic Syndrome in Male Schizophrenics.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeuroendocrine dysfunction is related to the pathogenesis of mental disorders, but conclusions from clinical research lack consistency. We aimed to investigate the neuroendocrinal pathophysiology and its correlation with clinical symptoms in patients with schizophrenia.
methodsThe present cross-sectional study included 486 inpatients with schizophrenia admitted at a psychiatric hospital in Shanghai within one year, and 154 healthy controls (HC) matched on age and gender. The serum hemoconcentrations of thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), adrenocorticotrophic hormone (ACTH), and cortisol (COR) were measured
resultsWhen compared to HC, the schizophrenia group showed elevated ACTH and COR levels and decreased TT3 and TT4 levels (
conclusionsDecreased TT3 and TT4 and elevated ACTH and COR levels appear to be associated with schizophrenia symptoms. The chronic recurrent trait of schizophrenia may cause long-term effects on FT3 and FT4 while changes in thyroid, and adrenal function as a result of mental disorder varied with gender. The pathophysiological parameters provide fair to good accuracy of these models.
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