ArticleMolecular vision2020
A negative correlation of axial length with aqueous humor concentration of cytokines in patients with congenital cataracts.
Article in Molecular vision, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Relationship between Axial Length and Levels of TGF-BioMed research international · 2021Trial
- Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study.Translational vision science & technology · 2025Article
- Genomic and GEO data integration identifies PDGFB as a potential therapeutic target for sepsis.Scientific reports · 2025Article
- Characteristic cytokine profile of the aqueous humor in eyes with congenital cataract and pre-existing posterior capsule dysfunction.Frontiers in medicine · 2024Article
- Elevated tissue transglutaminase levels in aqueous humor of congenital cataractous eyes with long axial length.Heliyon · 2023Article
- Aqueous Level of ANGPTL4 Correlates with the OCTA Metrics of Diabetic Macular Edema in NPDR.Journal of diabetes research · 2022Article
- Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children.Annals of translational medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the association between cytokine (and related proteins) concentrations in the aqueous humor (AH) of patients with congenital cataracts and preoperative and postoperative axial length. Methods: Samples from the AH were collected from 25 eyes of 17 patients with congenital cataracts who underwent congenital cataract extraction and intraocular lens implantation. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess the concentration of cytokines or chemokines, and acute phase proteins in the AH. Axial lengths were measured before surgery and at 3 months, 6 months, and 1 year after surgery. Results: The mean protein concentrations were determined in the AH of patients with congenital cataracts. The following proteins were assessed: VEGF (9.89 ± 4.94 pg/ml), TNF-α (1.88 ± 0.12 pg/ml), TGF-β2 (1622.88 ± 762.53 pg/ml), IL-1RA (110.78 ± 141.29 pg/ml), IL-1β (1.85 ± 0.13 pg/ml), IL-2 (41.96 ± 14.48 pg/ml), IL-4 (9.75 ± 1.32 pg/ml), IL-5 (1.38 ± 0.09 pg/ml), IL-6 (2.31 ± 5.97 pg/ml), IL-10 (1.46 ± 0.47 pg/ml), IL-12p70 (21.50 ± 1.60 pg/ml), IL-15 (2.23 ± 0.18 pg/ml), IL-17A (1.22 ± 0.11 pg/ml), GM-CSF (2.80 ± 0.38 pg/ml), IFN-γ (9.20 ± 0.42 pg/ml), CCL2/MCP-1 (131.45 ± 90.45 pg/ml), CCL3/MIP-1α (87.14±3.83 pg/ml), CCL4/MIP-1β (66.26 ± 2.22 pg/ml), CXCL10/IP-10 (13.99 ± 39.66 pg/ml), CCL11/eotaxin (27.17 ± 2.00 pg/ml), and PDGF-BB (0.43 ± 0.04 pg/ml). These data suggested a negative correlation between the level of VEGF in the AH and the preoperative axial length (r Conclusions: Increased preoperative axial lengths were negatively correlated with AH levels of VEGF, GM-CSF, and CCL11/eotaxin. The level of PDGF-BB was negatively correlated with the change in axial length 1 year post-surgery. These data suggest that the concentrations of these proteins in the AH may have predictive value for changes in axial length in patients with congenital cataracts, and possibly provide a useful prognostic modality.
Indexed as
Identifiers
32174750PMC7051862W3010891260What OpenQuestion holds
Registered trials
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