Evidence map›Paper›PMID 32174689›Full record

ReviewIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2020

Updates on Novel Erythropoiesis-Stimulating Agents: Clinical and Molecular Approach.

Zahra Moradi, Amirhosein Maali, Javad Sadeghi Shad, Alireza Farasat, Reza Kouchaki, Mona Moghadami, Mohamad Hosein Ahmadi, Mehdi Azad

Open access · greenAbstract readReview
In one paragraph

Review in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Erythropoietin and Ferulic Acid Loaded on FeApplied biochemistry and biotechnology · 2026
    Article
  3. Review
  4. Article
  5. The Association of Methylation Status and Expression Level ofInternational journal of hematology-oncology and stem cell research · 2023
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zahra Moradi1Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Amirhosein Maali2Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Javad Sadeghi Shad2Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Alireza Farasat5Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Reza Kouchaki6Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Mona Moghadami2Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Mohamad Hosein Ahmadi6Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Mehdi Azad6Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Qazvin University of Medical Sciences · IRBabol University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythropoietin (EPO) is an important hormone responsible for the stimulation of hematopoiesis which is impaired in a variety of diseases, such as chronic kidney disease, cancer chemotherapy, and the use of some anti-HIV drugs. Difficulties in the purification of endogenous EPO due to problems such as technical limitations, heterogeneity of target cells, inadequate amount and immunogenicity of the resultant product, had limited the entry of endogenous EPO in the clinical applications. The integration of medical biotechnology and hematology has introduced novel procedures for the production of human recombinant erythropoietin (rHuEPO), and other erythropoiesis-stimulating agents (ESAs). To investigate and produce rHuEPO, the first step is to recognize the molecular biology and functional pathways, structure, metabolism, and basic physiology of EPO. In this review, all clinical indications, side effects, challenges and notable points regarding EPO, rHuEPO, and other ESAs have also been addressed along with its molecular characterization, such as the modifications needed to optimize their rHuEPO biosynthesis.

Indexed as

Erythropoiesis-stimulating agentsErythropoietinHuman recombinant erythropoietin

Identifiers

PMID32174689
PMCPMC7042474
OpenAlexW2974678286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.