Evidence map›Paper›PMID 32174258›Full record

ArticleRNA biology2020

LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia.

Lijuan Chen, Xu Fan, Jianhua Zhu, Xuexin Chen, Yiling Liu, Hao Zhou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond.Journal of experimental & clinical cancer research : CR · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. The Role ofCancers · 2020
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lijuan ChenDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Xu FanLiver Research Center, Beijing Friendship Hospital, Capital Medical University , Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis & National Clinical Research Center for Digestive Diseases, Beijing, China.
Jianhua ZhuLaboratory of Clinical Immunology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Xuexin ChenInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Yiling LiuInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Hao ZhouInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China.
Huazhong University of Science and Technology · CNUnion Hospital · CNBeijing Friendship Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence or absence of cytogenetic mutations is proposed to be responsible for the pathogenesis of acute myeloid leukaemia (AML). However, the current classification system is inadequate to elucidate the molecular heterogeneity of the disease, and therapy failures frequently occur. Leukaemia stem cells (LSCs) initiate and maintain the clonal hierarchy of AML and exhibit properties of self-renewal remaining recalcitrant to conventional chemotherapy. In this study, we identified a novel long non-coding RNA (lncRNA) MAGI2 antisense RNA 3 (MAGI2-AS3) in AML and investigated its functional role in regulating LSCs self-renewal. LSCs were identified by immunoprofiling of CD34

Indexed as

DNA DemethylationPromoter Regions, GeneticRNA, Long NoncodingAdaptor Proteins, Signal TransducingCell Line, TumorCell Self RenewalDioxygenasesDNA-Binding ProteinsGene Expression Regulation, LeukemicGuanylate KinasesHumansLeukemia, Myeloid, AcuteMembrane GlycoproteinsNeoplastic Stem CellsProtein BindingProto-Oncogene ProteinsAdaptor Proteins, Signal TransducingDioxygenasesDNA-Binding ProteinsGuanylate KinasesLRIG1 protein, humanMAGI2 protein, humanMembrane GlycoproteinsProto-Oncogene ProteinsRNA, AntisenseRNA, Long NoncodingTET2 protein, humanacute Myeloid Leukaemiademethylationleukaemic Stem CellsLong Non-Coding RNALRIG1Magi2-AS3self-renewalTET2

Identifiers

PMID32174258
PMCPMC7549675
OpenAlexW3010674804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.