ReviewJournal of the American Heart Association2020
Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution.
Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of the literature on indoor air quality in healthcare units and its effects on health.BMC public health · 2025Pooled it
- Asthma and decreased lung function in children exposed to perfluoroalkyl and polyfluoroalkyl substances (PFAS): An updated meta-analysis unveiling research gaps.Environmental research · 2024Pooled it
- Early life cookstove interventions and children's blood pressure: Evidence from the Ghana randomized air pollution and health study.Environmental research · 2025Trial
- Cumulative vulnerabilities and smoking abstinence: A test from a randomized clinical trial.Behaviour research and therapy · 2023Trial
- Exposure to metals and morbidity at eight years follow-up in women of childbearing age.Scientific reports · 2021Trial
- Air Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Long-Term Ambient PMToxics · 2026Article
- Bridging the life-course exposome approach with a life-cycle perspective in safe and sustainable by design (SSbD) for chemical risk.Human genomics · 2026Article
- Association of PM2.5 exposure with 10-year atherosclerotic cardiovascular disease risk: a mediation analysis of blood and urinary biomarkers.Frontiers in public health · 2026Article
- Cumulative risk communication: comparing practitioner perspectives with public interpretation and response.BMC public health · 2025Article
- Modeling environmental noise pollution around the 1893 educational institutions for children in Tehran to support new urban design strategies.Scientific reports · 2025Article
- Combined impact of dynamic air pollution and transportation noise on cardiometabolic disorders in San Diego County.American journal of epidemiology · 2025Article
- Advancing translational exposomics: bridging genome, exposome and personalized medicine.Human genomics · 2025Review
- Prenatal and early life exposure to fine particulate matter and telomere length in early childhood.International journal of hygiene and environmental health · 2025Article
- Article
- Mitigating climate change impacts on health: a comparative analysis of strategies in Saudi Arabia and Lebanon.Frontiers in public health · 2025Article
- Cardiovascular health and economic outcomes under improved air quality in China: a modelling study.BMJ global health · 2024Article
- The Effects of Environmental Factors on General Human Health: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Prenatal and Early Life Exposure to Ambient Air Pollutants Is Associated with the Fecal Metabolome in the First Two Years of Life.Environmental science & technology · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years-1.8 billion children-breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.