ArticleJournal of the American Heart Association2020
Link Between Elevated Long-Term Resting Heart Rate Variability and Pulse Pressure Variability for All-Cause Mortality.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up.Journal of clinical medicine · 2026Article
- Long-term variability in physiological measures and risk of frailty: evidence from two cohort studies.The journal of nutrition, health & aging · 2026Article
- Socioeconomic disparities in physiological dysregulation: a longitudinal mediation analysis of cardiometabolic multimorbidity among middle-aged and elderly Chinese.BMC public health · 2025Observational
- Blood pressure variability supersedes heart rate variability as a real-world measure of dementia risk.Scientific reports · 2024Article
- Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China.BMC medicine · 2023Article
- Heart rate variability of elite female rowers in preparation for and during the national selection regattas: a pilot study on the relation to on water performance.Frontiers in sports and active living · 2023Article
- Effect of visit-to-visit blood pressure variability on mild cognitive impairment and probable dementia in hypertensive patients receiving standard and intensive blood pressure treatment.Frontiers in cardiovascular medicine · 2023Article
- Association of heart rate with cardiovascular events and mortality in hypertensive and normotensive population: a nationwide prospective cohort study.Annals of translational medicine · 2021Article
- Long-Term Visit-to-Visit Mean Arterial Pressure Variability and the Risk of Heart Failure and All-Cause Mortality.Frontiers in cardiovascular medicine · 2021Article
- Link Between Elevated Long-Term Resting Heart Rate Variability and Pulse Pressure Variability for All-Cause Mortality.Journal of the American Heart Association · 2020Article
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9 authors.
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Abstract
Background Elevated long-term systolic blood pressure and resting heart rate (RHR) variability are suggested to amplify the risk of all-cause mortality (ACM). However, the link between increased RHR and pulse pressure for ACM remained unclear. Methods and Results This study analyzed 46 751 individuals from Kailuan Cohort Study for the end outcome of ACM. A Cox regression model was used to estimate hazard ratios for death events. Kaplan-Meier analysis was performed to study the differences in survival as stratified by the SD, coefficient of variation, and average real variability of RHR and pulse pressure quartiles. A total of 1667 deaths (<65 years of age=866/40351, ≥65 years of age=801/6400) were recorded over 4.97±0.69 years follow-up. Participants under the age of 65 years in the third and fourth quartiles of pulse pressure SD had an independent increase in risk for ACM (hazard ratio [95% CI], 1.16 [1.06-1.28]; and 1.19 [1.05-1.35], respectively). Additionally, participants >65 years of age had a higher risk for ACM across quartiles of RHR-SD. The hazard ratio (95% CI) for the subjects in quartiles 2, 3, and 4 were 1.81 (1.10-2.97), 2.31 (1.37-1.3.90), and 2.64 (1.63-4.29), respectively. Conclusions An elevated long-term RHR variability combined with an increased pulse pressure variability or vice versa amplifies the risk of ACM.
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