ArticleAmerican journal of physiology. Renal physiology2020
Combinatorial expression of claudins in the proximal renal tubule and its functional consequences.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Assessment of low dietary inclusion of nutraceuticals derived from microalgae to enhance intestinal function in gilthead seabream (Sparus aurata) juveniles.Scientific reports · 2026Article
- Paracellular Transport and Renal Tubule Calcium Handling: Emerging Roles in Kidney Stone Disease.Journal of the American Society of Nephrology : JASN · 2024Review
- Biophysics of claudin proteins in tight junction architecture: Three decades of progress.Biophysical journal · 2024Review
- Molecular Dynamics Simulations of Claudin-10a and -10b Ion Channels: With Similar Architecture, Different Pore Linings Determine the Opposite Charge Selectivity.International journal of molecular sciences · 2024Article
- Integrating Continuous Transepithelial Flux Measurements into an Ussing Chamber Set-Up.International journal of molecular sciences · 2024Article
- High dietary KAmerican journal of physiology. Renal physiology · 2023Article
- Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.Nature communications · 2022Article
- Tight junction channel regulation by interclaudin interference.Nature communications · 2022Article
- Effects of fecal stream deprivation on human intestinal barrier after loop ileostomy.Journal of gastroenterology and hepatology · 2022Article
- Claudins in kidney health and disease.Kidney research and clinical practice · 2022Article
- Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dysregulation of Intestinal Physiology by Aflatoxicosis in the Gilthead Seabream (Frontiers in physiology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The proximal renal tubule (PT) is characterized by a highly conductive paracellular pathway, which contributes to a significant amount of solute and water reabsorption by the kidney. Claudins are tight junction proteins that, in part, determine the paracellular permeability of epithelia. In the present study, we determined the expression pattern of the major PT claudins. We found that claudin-2 and claudin-10 are coexpressed throughout the PT, whereas claudin-3 is coexpressed with claudin-2 predominantly in the proximal straight tubule. Additionally, claudin-2 and claudin-3 are expressed separately within mutually exclusive populations of descending thin limbs. We developed a novel double-inducible Madin-Darby canine kidney I cell model to characterize in vitro the functional effect of coexpression of PT claudins. In keeping with previous studies, we found that claudin-2 alone primarily increased cation (Na
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