Evidence map›Paper›PMID 32173908›Full record

ArticleMagnetic resonance in medicine2020

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized

Vencel Somai, Alan J Wright, Maria Fala, Friederike Hesse, Kevin M Brindle

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vencel SomaiCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Alan J WrightCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Maria FalaCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Friederike HesseCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
Kevin M BrindleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-3883-6287

Funding

Cancer Research UK 17242Cancer Research UK 28289Cancer Research UK A17197Cancer Research UK A28397Cancer Research UK A29580Cancer Research UK C197/A16465Cancer Research UK C55296/A26605Cancer Research UK C9685/A25177
6 · The paper itself

Abstract

purposeImaging tumor metabolism in vivo using hyperpolarized [1-

methodsThe sequence uses numerically optimized spectrally selective excitation pulses set to the resonant frequencies of pyruvate and lactate and a hyperbolic secant adiabatic refocusing pulse, all applied in the absence of slice selection gradients. The excitation pulses were designed to be resistant to the effects of B

resultsThe pulse sequence gave an isotropic PSF of 2.8 mm. The excitation profiles of the optimized pulses closely matched simulations and a 46.10 ± 0.04% gain in image SNR was observed compared to a conventional Shinnar-Le Roux excitation pulse. The sequence was demonstrated with dynamic imaging of hyperpolarized [1-

conclusionThe pulse sequence was capable of dynamic imaging of hyperpolarized

Indexed as

AlgorithmsImage EnhancementMagnetic Resonance ImagingPhantoms, ImagingPyruvic AcidSignal-To-Noise RatioPyruvic Acidhyperpolarizedimaginglactatepyruvatetumor

Identifiers

PMID32173908
PMCPMC8638674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.