Evidence map›Paper›PMID 32173886›Full record

Trial reportLasers in surgery and medicine2020

Transcranial Photobiomodulation (tPBM) With 1,064-nm Laser to Improve Cerebral Metabolism of the Human Brain In Vivo.

Tyrell Pruitt, Xinlong Wang, Anqi Wu, Elisa Kallioniemi, Mustafa M Husain, Hanli Liu

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lasers in surgery and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736092 (Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery), which is not on this map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07736092 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled130ConditionsOlder Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive RecoveryArmsTranscranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tyrell PruittDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, Texas, 76019.
Xinlong WangDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, Texas, 76019.
Anqi WuDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, Texas, 76019.
Elisa KallioniemiDepartment of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390.
Mustafa M HusainDepartment of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390.
Hanli LiuDepartment of Bioengineering, University of Texas at Arlington, 500 UTA Blvd, Arlington, Texas, 76019.ORCID 0000-0002-9312-5691
The University of Texas at Arlington · USSouthwestern Medical Center · US

Funding

Novel Neuromodulation by Transcranial Infrared Brain Stimulation with ImagingRF1MH114285 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GONZALEZ-LIMA, FRANCISCO, LIU, HANLI · 2017 to 2017
$2.9M
NIMH NIH HHS RF1 MH114285
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn our previous proof-of-principle study, transcranial photobiomodulation (tPBM) with 1,064-nm laser was reported to significantly increase concentration changes of oxygenated hemoglobin (∆[HbO]) and oxidized-state cytochrome c oxidase (∆[oxi-CCO]) in the human brain. This paper further investigated (i) its validity in two different subsets of young human subjects at two study sites over a period of 3 years and (ii) age-related effects of tPBM by comparing sham-controlled increases of ∆[HbO] and ∆[oxi-CCO] between young and older adults. STUDY DESIGN/MATERIALS AND

methodsWe measured sham-controlled ∆[HbO] and ∆[oxi-CCO] using broadband near-infrared spectroscopy (bb-NIRS) in 15 young (26.7 ± 2.7 years of age) and 5 older (68.2 ± 4.8 years of age) healthy normal subjects before, during, and after right-forehead tPBM/sham stimulation with 1,064-nm laser. Student t tests were used to test statistical differences in tPBM-induced ∆[HbO] and ∆[oxi-CCO] (i) between the 15 young subjects and those of 11 reported previously and (ii) between the two age groups measured in this study.

resultsStatistical analysis showed that no significant difference existed in ∆[HbO] and ∆[oxi-CCO] during and post tPBM between the two subsets of young subjects at two study sites over a period of 3 years. Furthermore, the two age groups showed statistically identical net increases in sham-controlled ∆[HbO] and ∆[oxi-CCO].

conclusionsThis study provided strong evidence to validate/confirm our previous findings that tPBM with 1,064-nm laser enables to increase cerebral ∆[HbO] and ∆[oxi-CCO] in the human brain, as measured by bb-NIRS. Overall, it demonstrated the robust reproducibility of tPBM being able to improve cerebral hemodynamics and metabolism of the human brain in vivo in both young and older adults. Lasers Surg. Med. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.

Indexed as

BrainSpectroscopy, Near-InfraredAgedChild, PreschoolHemodynamicsHumansLasersReproducibility of Resultsbroadband near-infrared spectroscopycytochrome c oxidasereproducibilitytPBMtranscranial photobiomodulation

Identifiers

PMID32173886
PMCPMC7492377
OpenAlexW3011049040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.