ArticleJournal of assisted reproduction and genetics2020
The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Live Birth After Oocyte Donation In Vitro Fertilization Cycles in Women With Endometriosis: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- The Building and Application of a Machine Learning Model on Predicting Euploid Blastocysts in IVF Treatments Without PGT-A.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Article
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Metroplasty before IVF in women with a T-shaped uterus: A clinical challenge.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Embryological and clinical predictors of implantation and live birth in 3000 single euploid embryo transfer cycles: a retrospective cohort study.Archives of gynecology and obstetrics · 2026Article
- Aging Regulates Receptivity by Modulating the Expression of Osteopontin and HOXA10 in the Human Endometrium.Journal of clinical medicine · 2026Article
- Pregnancy outcomes after fresh and frozen embryo transfer in women of advanced age and analysis of influencing factors: single-center experience.Frontiers in endocrinology · 2026Article
- Beyond aneuploidy: embryo morphology, maternal age, and miscarriage dynamics in PGT-A selected single embryo transfer.Journal of assisted reproduction and genetics · 2026Article
- Effect of assisted hatching on pregnancy outcomes following 1,678,872 single embryo transfers based on the Japan Assisted Reproductive Technology Registry.Scientific reports · 2025Article
- Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles.BMC pregnancy and childbirth · 2025Article
- Investigating Aging-Related Endometrial Dysfunction Using Endometrial Organoids.Cell proliferation · 2025Article
- Surfing follicular waves in ovarian stimulation: is there a role for LH in DuoStim protocols? A narrative review and SWOT analysis.Reproductive biology and endocrinology : RB&E · 2025Review
- Maternal age-related declines in live birth rate following single euploid embryo transfer: a retrospective cohort study.Journal of ovarian research · 2025Article
- Delayed blastulation and pregnancy outcomes in single frozen-thawed euploid blastocyst transfer.Frontiers in endocrinology · 2025Article
- Analysis of factors associated with IVF/ICSI clinical outcomes in advanced maternal age patients with normal ovarian reserve under the POSEIDON criteria.Frontiers in endocrinology · 2025Article
- Application and Prospects of Long-Read Sequencers for Preimplantation Genetic Testing for Structural Rearrangements.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Dendritic cells under the control of the preimplantation embryo secretome: an in vitro study.Reproductive biology and endocrinology : RB&E · 2024Article
- Association between Age and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study.Iranian journal of public health · 2024Article
- Acupuncture improves the live birth of patients with repeated implantation failure: a retrospective cohort study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe rate of embryonic aneuploidy increases with increasing female age and is the primary cause of lower pregnancy and live birth rates (LBR) in older reproductive age women. This retrospective cohort study evaluates single euploid embryo transfers to determine whether an age-related decline in reproductive efficiency persists.
methodsA total of 8175 non-donor single embryo transfers (SET) after pre-implantation testing for aneuploidy (PGT-A) and cryopreservation were included. These were divided into five groups by patient age: < 35 years old (n = 3789 embryos transferred), 35-37 (n = 2200), 38-40 (n = 1624), 41-42 (n = 319), and > 42 (n = 243). Implantation rate (IR), clinical pregnancy rate (CPR), and LBR were calculated for each group as a percentage of embryos transferred and compared. CPR was also analyzed as a percentage of implanted pregnancies, and LBR as a percentage of clinical pregnancies, to determine when age has the greatest impact. These results were then adjusted for confounding variables via a multivariate logistic regression model.
resultsImplantation rates negatively correlated with age. After adjusting for confounders, women 38 years or older had a significantly lower IR than those under 35 (OR 0.85, 95%CI 0.73-0.99 for 38-40 years old; 0.69, 0.53-0.91 for 41-42, and 0.69, 0.51-0.94 for > 42). These differences are also apparent in CPR and LBR. The rates of progression to clinical pregnancy and live birth did not differ significantly by age group. Other factors observed to affect IR independently were anti-Müllerian hormone (AMH), day of embryo transfer, and embryo morphology.
conclusionWhile selection of euploid embryos may be effective in overcoming a significant proportion of the age-related decline in reproductive efficiency, a decrease in IR, CPR, and LBR persists even when analyzing only euploid embryo transfers. The observed impact of aging is, therefore, independent of ploidy, as well as of other variables that affect reproductive efficiency. These results indicate that factors other than aneuploidy contribute to reproductive senescence.
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