ArticleInternational journal of colorectal disease2020
International incidence trends in early- and late-onset colorectal cancer: a population-based study.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- At what age should people with obesity start colorectal cancer screening?International journal of cancer · 2026Pooled it
- Epidemiology of colonic adenoma and cancer.Clinical endoscopy · 2026Review
- Is the incidence of early-onset cancers increasing in the northeast of Italy? A 30-year analysis of the regional cancer registration data by age, 1987-2019.International journal of cancer · 2026Observational
- Family mutuality enhances the family resilience of colorectal cancer patients through positive family functioning.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification.Journal of the National Cancer Institute · 2025Article
- Rising Incidence and Mortality of Colorectal Cancer in Young African Adults: Need for a Better Care Plan.Cureus · 2025Review
- Association between Socioeconomic Inequality and the Burden of Colon and Rectum Cancer in Asia: GLOBOCAN Sources and Methods.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Prehabilitation in Frail Octogenarian and Nonagenarian Patients in Colorectal Cancer Surgery: Short- and Medium-Term Outcomes.Journal of clinical medicine · 2024Article
- Contribution of PKS+Heliyon · 2024Article
- Temporal trends in age- and stage-specific incidence of colorectal adenocarcinomas in Germany.BMC cancer · 2023Article
- Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition.Cancers · 2023Review
- Temporal trends of migraine and tension-type headache burden across the BRICS: implications from the Global Burden of Disease study 2019.Frontiers in neurology · 2023Article
- The Insulin-like Growth Factor System and Colorectal Cancer.Life (Basel, Switzerland) · 2022Review
- Incidence trends for twelve cancers in younger adults-a rapid review.British journal of cancer · 2022Review
- Gastrointestinal Adenocarcinoma Incidence and Survival Trends in South Australia, 1990-2017.Cancers · 2022Article
- Epidemiology and biology of early onset colorectal cancer.EXCLI journal · 2022Review
- Survival in colon and rectal cancers in Finland and Sweden through 50 years.BMJ open gastroenterology · 2021Article
- Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study.World journal of gastrointestinal surgery · 2021Article
- PPARG expression in colorectal cancer and its association with staging and clinical evolution.Acta cirurgica brasileira · 2020Article
- What Is the Evidence Base Regarding Early Onset Colorectal Cancer in Australia and New Zealand? A Scoping Review.ANZ journal of surgeryArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeKnowing the global incidence of colorectal cancer (CRC), by sex and age of onset, is of great importance for understanding the disease burden of CRC.
methodsThe CRC incidence data, by cancer site, age of onset, sex, country, and year, were retrieved from the Cancer Incidence in Five Continents Vol. Plus database. Estimated annual percentage changes (EAPC) were calculated to quantify the temporal trends in the CRC age-standardized incidence rate.
resultsGlobally, the incidence of late-onset CRC was heterogeneous and remained increasing in most countries. The highest incidence of late-onset colon and rectal cancer was both found in males in Slovakia (156.5/100,000 and 121.5/100,000, respectively). The most pronounced increases were mostly observed in developing countries, such as Brazil (colon cancer: EAPC = 5.87, 95% CI 3.18, 8.63; rectal cancer: EAPC = 4.68; 95% CI 2.78, 6.62). The highest incidence of early-onset colon and rectal cancer was found in females in Switzerland (4.2/100,000) and in males in South Korea (4.6/100,000), respectively. The incidences of early-onset CRC were increased in parts of countries, including countries experiencing a decline in late-onset CRC incidence, such as the USA, Germany, and Australia. The temporal trends of colon cancer were mostly aligned with those of rectal in most countries, independent of sex and age of onset.
conclusionThe increase of early-onset CRC incidence suggests more prevention initiatives are urgently warranted for young adults in the near future. Targeted and effective prevention measures are still needed among elderly populations.
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