ArticlePsychopharmacology2020
Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption.
Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Effect and mechanism of father's companionship on defensive attack behavior of adult male offspring mice.Communications biology · 2025Article
- C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis.Psychopharmacology · 2025Article
- Assessment of the effects of sex, age, and rearing condition on ultrasonic vocalizations elicited by pups during the maternal potentiation paradigm in C57BL/6J mice.Developmental psychobiology · 2022Article
- Social behavior in 16p11.2 and 22q11.2 copy number variations: Insights from mice and humans.Genes, brain, and behavior · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleSocial attachment plays an important role in offspring development. Different parenting experiences during lactation may shape offspring behavior and later alcohol use.
objectivesWe tested the hypothesis that differential rearing conditions (single mother, SM or biparental, BP) in the non-monogamous C57BL/6J mice may affect (1) parental behavior during lactation, (2) adolescent behavior, and (3) adolescent initiation of alcohol drinking.
methodsMice were reared in SM or BP (cohabitation of father-mother since copulation) condition until weaning (postnatal day, PND, 21). Litters from both conditions were filmed during PNDs 6, 9, and 12 and an ethogram was made taking into account nest-, pup-, or self-directed behaviors. At PNDs, 28-29 adolescent animals were evaluated in a modified version of the concentric square field for measurement of behavioral patterns. Other groups of adolescents were tested in a 4-h daily, two-bottle choice alcohol consumption test (10% alcohol vs. water) during 3 weeks (4 days per week).
resultsSingle mothers spent less time in the nest, left unattended the nest more times, displayed more self-directed and less pup-directed behaviors than BP parents. SM-reared adolescents displayed more anxiogenic-like and less risk-associated behaviors than BP counterparts. The alcohol consumption test indicated a strong effect of rearing condition. Since the fifth day of test, SM adolescents consumed more quantities of alcohol than BP adolescents.
conclusionsDuring single-mother parenting, pups are left unattended more often, and during adolescence, these organisms exhibited increased anxiety responses. This behavioral phenotype may act as a risk factor for alcohol initiation during adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.