Evidence map›Paper›PMID 32173491›Full record

ArticleChest2020

Pulmonary Vascular and Right Ventricular Burden During Exercise in Interstitial Lung Disease.

Rudolf K F Oliveira, Aaron B Waxman, Paul J Hoover, Paul F Dellaripa, David M Systrom

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Exercise-Induced Pulmonary Hypertension: What Is New?Journal of cardiovascular development and disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rudolf K F OliveiraDivision of Respiratory Diseases, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.
Aaron B WaxmanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Heart & Vascular Center, Brigham and Women's Hospital, Boston, MA.
Paul J HooverDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Paul F DellaripaDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
David M SystromDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Heart & Vascular Center, Brigham and Women's Hospital, Boston, MA. Electronic address: dsystrom@bwh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USUniversidade Federal de São Paulo · BR

Funding

Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
Regional Measurement of Alveolar Partial Pressure of Oxygen with HPXe MRI.R21HL125999 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MURADYAN, IGA · 2015 to 2016
$488k
NHLBI NIH HHS R21 HL125999NHLBI NIH HHS U01 HL125215
6 · The paper itself

Abstract

backgroundPulmonary hypertension (PH) adversely affects patient's exercise capacity in interstitial lung disease (ILD). The impact of pulmonary vascular and right ventricular (RV) dysfunction, however, has traditionally been believed to be mild and clinically relevant principally in advanced lung disease states. RESEARCH QUESTION: The aim of this study was to evaluate the relative contributions of pulmonary mechanics, pulmonary vascular function, and RV function to the ILD exercise limit. STUDY DESIGN AND

methodsForty-nine patients with ILD who underwent resting right heart catheterization followed by invasive exercise testing were evaluated. Patients with PH at rest (ILD + rPH) and with PH diagnosed exclusively during exercise (ILD + ePH) were contrasted with ILD patients without PH (ILD non-PH).

resultsPeak oxygen consumption was reduced in ILD + rPH (61 ± 10% predicted) and ILD + ePH (67 ± 13% predicted) compared with ILD non-PH (81 ± 16% predicted; P < .001 and P = .016, respectively). Each ILD hemodynamic phenotype presented distinct patterns of dynamic changes of pulmonary vascular compliance relative to pulmonary vascular resistance from rest to peak exercise. Peak RV stroke work index was increased in ILD + ePH (24.7 ± 8.2 g/m

interpretationILD with resting and exercise PH is associated with increased exercise RV work, reduced pulmonary vascular reserve, and reduced peak oxygen consumption. The findings highlight the role of pulmonary vascular and RV burden to ILD exercise limit.

Indexed as

AdultAgedCase-Control StudiesExerciseExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLung Diseases, InterstitialMaleMiddle AgedOxygen ConsumptionRespiratory MechanicsVascular ResistanceVentricular Dysfunction, Rightexercisehemodynamicsinterstitial lung diseasepulmonary hypertensionright ventricle

Identifiers

PMID32173491
PMCPMC8173767
OpenAlexW3011770530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.