ArticleThe Journal of allergy and clinical immunology2020
Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency.
Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis.Chest · 2026Article
- Triggering mechanisms of acute thunderstorm asthma: epithelial barrier disruption and immune dysregulation.Respiratory research · 2026Review
- Precision Medicine for Asthma: Tailored to its Severity and Endotype/Phenotype.Allergy, asthma & immunology research · 2026Review
- Airway mucus andERJ open research · 2025Article
- A method for MRI-guided bronchoscopy to identify obstructed airway segments.Physiological reports · 2025Article
- Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal BreathingRadiology. Cardiothoracic imaging · 2023Article
- Functional imaging in asthma and COPD: design of the NOVELTY ADPro substudy.ERJ open research · 2023Article
- Comparison of hyperpolarizedFrontiers in physiology · 2023Article
- Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling.Advances in experimental medicine and biology · 2023Article
- Biologics and airway remodeling in severe asthma.Allergy · 2022Review
- Lung MRI with hyperpolarised gases: current & future clinical perspectives.The British journal of radiology · 2022Review
- Observational
- Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.Respirology (Carlton, Vic.) · 2022Review
- Small Airways: The "Silent Zone" of 2021 GINA Report?Frontiers in medicine · 2022Review
- Xenon ventilation MRI in difficult asthma: initial experience in a clinical setting.ERJ open research · 2021Article
- Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: a 1-year pilot randomised trial.ERJ open research · 2021Article
- Pulmonary Functional Imaging: Part 2-State-of-the-Art Clinical Applications and Opportunities for Improved Patient Care.Radiology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is an unmet need for an objective biomarker to predict asthma exacerbations.
objectiveOur aim was to assess the ventilation defect percent (VDP) on hyperpolarized helium-3 magnetic resonance imaging as a predictor of exacerbation frequency following imaging.
methodsSubjects underwent hyperpolarized helium-3 and conventional clinical measurements, including pulmonary function tests, during a period of disease stability, and exacerbations were recorded prospectively over the following 2 years. We used a Poisson regression tree model to estimate an optimal VDP threshold for classifying subjects into high- versus low-exacerbation groups and then used statistical regression to compare this VDP threshold against conventional clinical measures as predictors of exacerbations.
resultsA total of 67 individuals with asthma (27 males and 40 females, 28 with mild-to-moderate asthma and 39 with severe asthma) had a median VDP of 3.75% (1.2% [first quartile]-7.9% [third quartile]). An optimal VDP threshold of 4.28% was selected on the basis of the maximum likelihood estimation of the regression tree model. Subjects with a VDP greater than 4.28% (n = 32) had a median of 1.5 exacerbations versus 0.0 for subjects with a VDP less than 4.28% (n = 35). In a stepwise multivariate regression model, a VDP greater than 4.28% was associated with an exacerbation incidence rate ratio of 2.5 (95% CI = 1.3-4.7) versus a VDP less than or equal to 4.28%. However, once individual medical history was included in the model, VDP was no longer significant. Nonetheless, VDP may provide an objective and complementary quantitative marker of individual exacerbation risk that is useful for monitoring individual change in disease status, selecting patients for therapy, and assessing treatment response.
conclusionVDP measured with magnetic resonance imaging shows promise as a biomarker of prospective asthma exacerbations.
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